Entry Database : PDB / ID : 4b99 Structure visualization Downloads & linksTitle Crystal Structure of MAPK7 (ERK5) with inhibitor ComponentsMITOGEN-ACTIVATED PROTEIN KINASE 7 Details Keywords TRANSFERASE / INHIBITORFunction / homology Function and homology informationFunction Domain/homology Component
Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK / ERKs are inactivated / enzyme inhibitor activity / mitogen-activated protein kinase binding / negative regulation of calcineurin-NFAT signaling cascade ... Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK / ERKs are inactivated / enzyme inhibitor activity / mitogen-activated protein kinase binding / negative regulation of calcineurin-NFAT signaling cascade / ERK/MAPK targets / negative regulation of smooth muscle cell apoptotic process / RET signaling / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / MAP kinase activity / mitogen-activated protein kinase / regulation of angiogenesis / negative regulation of endothelial cell apoptotic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / cellular response to transforming growth factor beta stimulus / positive regulation of protein metabolic process / adenylate cyclase-activating G protein-coupled receptor signaling pathway / PML body / cellular response to growth factor stimulus / negative regulation of inflammatory response / cellular response to hydrogen peroxide / MAPK cascade / Senescence-Associated Secretory Phenotype (SASP) / cell differentiation / intracellular signal transduction / cell cycle / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ... Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Elkins, J.M. / Wang, J. / Vollmar, M. / Mahajan, P. / Savitsky, P. / Deng, X. / Gray, N.S. / Pike, A.C.W. / von Delft, F. / Bountra, C. ...Elkins, J.M. / Wang, J. / Vollmar, M. / Mahajan, P. / Savitsky, P. / Deng, X. / Gray, N.S. / Pike, A.C.W. / von Delft, F. / Bountra, C. / Arrowsmith, C. / Edwards, A. / Knapp, S. CitationJournal : J.Med.Chem. / Year : 2013Title : X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.Authors : Elkins, J.M. / Wang, J. / Deng, X. / Pattison, M.J. / Arthur, S. / Erazo, T. / Gomez, N. / Lizcano, J.M. / Gray, N.S. / Knapp, S. History Deposition Sep 3, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 19, 2012 Provider : repository / Type : Initial releaseRevision 1.1 May 22, 2013 Group : Database referencesRevision 1.2 Jun 26, 2013 Group : Database referencesRevision 1.3 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.4 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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