- PDB-4au7: The structure of the Suv4-20h2 ternary complex with histone H4 -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 4au7
Title
The structure of the Suv4-20h2 ternary complex with histone H4
Components
HISTONE H4 PEPTIDE
HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2
Keywords
TRANSFERASE / EPIGENETICS
Function / homology
Function and homology information
: / heterochromatin => GO:0000792 / condensed chromosome, centromeric region => GO:0000779 / : / Inhibition of DNA recombination at telomere / Deposition of new CENPA-containing nucleosomes at the centromere / [histone H4]-N-methyl-L-lysine20 N-methyltransferase / SUMOylation of chromatin organization proteins / DNA Damage/Telomere Stress Induced Senescence / G2/M DNA damage checkpoint ...: / heterochromatin => GO:0000792 / condensed chromosome, centromeric region => GO:0000779 / : / Inhibition of DNA recombination at telomere / Deposition of new CENPA-containing nucleosomes at the centromere / [histone H4]-N-methyl-L-lysine20 N-methyltransferase / SUMOylation of chromatin organization proteins / DNA Damage/Telomere Stress Induced Senescence / G2/M DNA damage checkpoint / Recognition and association of DNA glycosylase with site containing an affected purine / HDMs demethylate histones / Cleavage of the damaged purine / Nonhomologous End-Joining (NHEJ) / [histone H4]-lysine20 N-methyltransferase / Condensation of Prophase Chromosomes / HDACs deacetylate histones / histone H4K20 methyltransferase activity / PRC2 methylates histones and DNA / Processing of DNA double-strand break ends / HATs acetylate histones / PKMTs methylate histone lysines / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / RMTs methylate histone arginines / positive regulation of isotype switching / Estrogen-dependent gene expression / S-adenosyl-L-methionine binding / positive regulation of double-strand break repair via nonhomologous end joining / protein localization to CENP-A containing chromatin / pericentric heterochromatin / CENP-A containing nucleosome / structural constituent of chromatin / nucleosome / nucleosome assembly / chromatin organization / histone binding / protein heterodimerization activity / DNA repair / chromatin binding / DNA binding / nucleoplasm / nucleus / metal ion binding Similarity search - Function
Resolution: 2.07→55.33 Å / Cor.coef. Fo:Fc: 0.952 / Cor.coef. Fo:Fc free: 0.925 / SU B: 8.589 / SU ML: 0.123 / Cross valid method: THROUGHOUT / ESU R: 0.217 / ESU R Free: 0.186 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. THE C-TERMINUS OF MOECULE B IS DISORDERED
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.24039
1570
5 %
RANDOM
Rwork
0.19255
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obs
0.19498
29593
97.05 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK