Entry Database : PDB / ID : 4alg Structure visualization Downloads & linksTitle N-Terminal Bromodomain of Human BRD2 With IBET-151 ComponentsBROMODOMAIN-CONTAINING PROTEIN 2 Details Keywords SIGNALING PROTEIN / INHIBITOR / HISTONE / EPIGENETIC READERFunction / homology Function and homology informationFunction Domain/homology Component
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ... acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein phosphorylation / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm Similarity search - Function NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. ... NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Chung, C. / Lamotte, Y. / Donche, F. / Bouillot, A. / Mirguet, O. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2012Title : Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).Authors: Seal, J. / Lamotte, Y. / Donche, F. / Bouillot, A. / Mirguet, O. / Gellibert, F. / Nicodeme, E. / Krysa, G. / Kirilovsky, J. / Beinke, S. / Mccleary, S. / Rioja, I. / Bamborough, P. / Chung, ... Authors : Seal, J. / Lamotte, Y. / Donche, F. / Bouillot, A. / Mirguet, O. / Gellibert, F. / Nicodeme, E. / Krysa, G. / Kirilovsky, J. / Beinke, S. / Mccleary, S. / Rioja, I. / Bamborough, P. / Chung, C. / Gordon, L. / Lewis, T. / Walker, A.L. / Cutler, L. / Lugo, D. / Wilson, D.M. / Witherington, J. / Lee, K. / Prinjha, R.K. History Deposition Mar 3, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 4, 2012 Provider : repository / Type : Initial releaseRevision 1.1 May 15, 2019 Group : Data collection / Experimental preparation / OtherCategory : exptl_crystal_grow / pdbx_database_proc / pdbx_database_statusItem : _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approvalRevision 1.2 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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