Entry Database : PDB / ID : 3zyu Structure visualization Downloads & linksTitle Crystal Structure of the first bromodomain of human BRD4 in complex with I-BET151(GSK1210151A) ComponentsBROMODOMAIN-CONTAINING PROTEIN 4 Details Keywords SIGNALING PROTEIN / BROMODOMAIN / I-151 / INHIBITOR / HISTONE / EPIGENETIC READERFunction / homology Function and homology informationFunction Domain/homology Component
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus Similarity search - Function Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Chung, C.W. / Mirguet, O. CitationJournal : Nature / Year : 2011Title : Inhibition of Bet Recruitment to Chromatin as an Effective Treatment for Mll-Fusion Leukaemia.Authors: Dawson, M.A. / Prinjha, R.K. / Dittman, A. / Giotopoulos, G. / Bantscheff, M. / Chan, W.I. / Robson, S.C. / Chung, C.W. / Hopf, C. / Savitski, M.M. / Huthmacher, C. / Gudgin, E. / Lugo, D. / ... Authors : Dawson, M.A. / Prinjha, R.K. / Dittman, A. / Giotopoulos, G. / Bantscheff, M. / Chan, W.I. / Robson, S.C. / Chung, C.W. / Hopf, C. / Savitski, M.M. / Huthmacher, C. / Gudgin, E. / Lugo, D. / Beinke, S. / Chapman, T.D. / Roberts, E.J. / Soden, P.E. / Auger, K.R. / Mirguet, O. / Doehner, K. / Delwel, R. / Burnett, A.K. / Jeffrey, P. / Drewes, G. / Lee, K. / Huntly, B.J. / Kouzarides, T. History Deposition Aug 25, 2011 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 2, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Nov 9, 2011 Group : Database referencesRevision 1.2 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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