Entry Database : PDB / ID : 3znx Structure visualization Downloads & linksTitle Crystal structure of the OTU domain of OTULIN D336A mutant ComponentsPROTEIN FAM105B Details Keywords HYDROLASEFunction / homology Function and homology informationFunction Domain/homology Component
protein linear deubiquitination / LUBAC complex / nucleotide-binding oligomerization domain containing 2 signaling pathway / regulation of tumor necrosis factor-mediated signaling pathway / regulation of canonical Wnt signaling pathway / sprouting angiogenesis / negative regulation of NF-kappaB transcription factor activity / cysteine-type peptidase activity / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / Regulation of TNFR1 signaling ... protein linear deubiquitination / LUBAC complex / nucleotide-binding oligomerization domain containing 2 signaling pathway / regulation of tumor necrosis factor-mediated signaling pathway / regulation of canonical Wnt signaling pathway / sprouting angiogenesis / negative regulation of NF-kappaB transcription factor activity / cysteine-type peptidase activity / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / Regulation of TNFR1 signaling / Wnt signaling pathway / negative regulation of inflammatory response / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / protein ubiquitination / innate immune response / proteolysis / cytoplasm / cytosol Similarity search - FunctionBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.35 Å DetailsAuthors Keusekotten, K. / Elliott, P.R. / Glockner, L. / Kulathu, Y. / Wauer, T. / Krappmann, D. / Hofmann, K. / Komander, D. CitationJournal : Cell(Cambridge,Mass.) / Year : 2013Title : Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.Authors : Keusekotten, K. / Elliott, P.R. / Glockner, L. / Fiil, B.K. / Damgaard, R.B. / Kulathu, Y. / Wauer, T. / Hospenthal, M.K. / Gyrd-Hansen, M. / Krappmann, D. / Hofmann, K. / Komander, D. History Deposition Feb 18, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 26, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_alt_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_alt_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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