- PDB-3wwt: Crystal Structure of the Y3:STAT1ND complex -
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基本情報
登録情報
データベース: PDB / ID: 3wwt
タイトル
Crystal Structure of the Y3:STAT1ND complex
要素
C' protein
Signal transducer and activator of transcription 1-alpha/beta
キーワード
TRANSCRIPTION/VIRAL PROTEIN / alpha protein / interferon inhibition / signal transduction / transcriptional activation / TRANSCRIPTION-VIRAL PROTEIN complex
機能・相同性
機能・相同性情報
metanephric mesenchymal cell differentiation / negative regulation of metanephric nephron tubule epithelial cell differentiation / negative regulation by virus of viral protein levels in host cell / renal tubule development / ISGF3 complex / response to interferon-beta / metanephric mesenchymal cell proliferation involved in metanephros development / interleukin-27-mediated signaling pathway / negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / CCR5 chemokine receptor binding ...metanephric mesenchymal cell differentiation / negative regulation of metanephric nephron tubule epithelial cell differentiation / negative regulation by virus of viral protein levels in host cell / renal tubule development / ISGF3 complex / response to interferon-beta / metanephric mesenchymal cell proliferation involved in metanephros development / interleukin-27-mediated signaling pathway / negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / CCR5 chemokine receptor binding / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / tumor necrosis factor receptor binding / Signaling by cytosolic FGFR1 fusion mutants / blood circulation / Interleukin-27 signaling / Interleukin-35 Signalling / positive regulation of mesenchymal cell proliferation / NOTCH3 Intracellular Domain Regulates Transcription / macrophage derived foam cell differentiation / histone acetyltransferase binding / type I interferon-mediated signaling pathway / Interleukin-20 family signaling / Interleukin-6 signaling / positive regulation of nitric-oxide synthase biosynthetic process / negative regulation of endothelial cell proliferation / ubiquitin-like protein ligase binding / response to type II interferon / positive regulation of interferon-alpha production / cell surface receptor signaling pathway via JAK-STAT / cellular response to organic cyclic compound / Regulation of IFNA/IFNB signaling / cellular response to interferon-beta / RNA polymerase II core promoter sequence-specific DNA binding / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / type II interferon-mediated signaling pathway / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / Regulation of IFNG signaling / Growth hormone receptor signaling / negative regulation of canonical NF-kappaB signal transduction / response to mechanical stimulus / Signaling by CSF3 (G-CSF) / positive regulation of defense response to virus by host / tumor necrosis factor-mediated signaling pathway / response to cAMP / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / Downstream signal transduction / negative regulation of angiogenesis / response to nutrient / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / transcription corepressor binding / positive regulation of erythrocyte differentiation / response to cytokine / protein phosphatase 2A binding / nuclear receptor binding / virion component / promoter-specific chromatin binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / positive regulation of smooth muscle cell proliferation / Signaling by SCF-KIT / response to hydrogen peroxide / PKR-mediated signaling / Inactivation of CSF3 (G-CSF) signaling / cellular response to type II interferon / ISG15 antiviral mechanism / response to peptide hormone / transcription coactivator binding / defense response / RNA polymerase II transcription regulator complex / cellular response to insulin stimulus / Signaling by CSF1 (M-CSF) in myeloid cells / Regulation of RUNX2 expression and activity / Interferon gamma signaling / Interferon alpha/beta signaling / Signaling by ALK fusions and activated point mutants / regulation of cell population proliferation / histone binding / double-stranded DNA binding / Interleukin-4 and Interleukin-13 signaling / defense response to virus / regulation of apoptotic process / host cell cytoplasm / DNA-binding transcription factor activity, RNA polymerase II-specific / symbiont-mediated suppression of host innate immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / cadherin binding / response to xenobiotic stimulus / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / axon / virus-mediated perturbation of host defense response / dendrite / chromatin / regulation of transcription by RNA polymerase II / nucleolus / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm 類似検索 - 分子機能
Paramyxovirus non-structural protein C / Paramyxovirus non-structural protein C / Transcription Factor, Stat-4 / STAT transcription factor, N-terminal domain / Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal / STAT1, SH2 domain / STAT1, C-terminal domain superfamily / STAT1 TAZ2 binding domain / : / Signal transducer and activator of transcription, linker domain ...Paramyxovirus non-structural protein C / Paramyxovirus non-structural protein C / Transcription Factor, Stat-4 / STAT transcription factor, N-terminal domain / Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal / STAT1, SH2 domain / STAT1, C-terminal domain superfamily / STAT1 TAZ2 binding domain / : / Signal transducer and activator of transcription, linker domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / STAT protein, all-alpha domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / p53-like transcription factor, DNA-binding / SH2 domain / Src homology 2 (SH2) domain profile. / SH2 domain / SH2 domain superfamily / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性
C' protein / Signal transducer and activator of transcription 1-alpha/beta 類似検索 - 構成要素