登録情報 | データベース: PDB / ID: 3wu0 |
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タイトル | Crystal structure of phosphorylated ETS-1 DNA binding and autoinhibitory domains (276-441) |
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要素 | Protein C-ets-1 |
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キーワード | TRANSCRIPTION / PHOSPHORYLATION / ETS-1 / AUTOINHIBITION / ETS DOMAIN / DNA-BINDING / ISOPEPTIDE BOND / NUCLEUS / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSCRIPTION REGULATION |
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機能・相同性 | 機能・相同性情報
PML body organization / positive regulation of leukocyte adhesion to vascular endothelial cell / negative regulation of cell cycle / positive regulation of blood vessel endothelial cell migration / regulation of angiogenesis / positive regulation of endothelial cell migration / transcription corepressor binding / positive regulation of erythrocyte differentiation / positive regulation of miRNA transcription / nuclear receptor coactivator activity ...PML body organization / positive regulation of leukocyte adhesion to vascular endothelial cell / negative regulation of cell cycle / positive regulation of blood vessel endothelial cell migration / regulation of angiogenesis / positive regulation of endothelial cell migration / transcription corepressor binding / positive regulation of erythrocyte differentiation / positive regulation of miRNA transcription / nuclear receptor coactivator activity / cell motility / Oncogene Induced Senescence / positive regulation of inflammatory response / positive regulation of angiogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / regulation of apoptotic process / nucleic acid binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription cis-regulatory region binding / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / immune response / DNA-binding transcription factor activity / negative regulation of cell population proliferation / response to antibiotic / regulation of transcription by RNA polymerase II / positive regulation of gene expression / positive regulation of DNA-templated transcription / chromatin / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleus / cytoplasm類似検索 - 分子機能 Protein C-ets-1, pointed domain / Transforming protein C-ets / Ets1, N-terminal flanking region of Ets domain / Ets1 N-terminal flanking region of Ets domain / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 1. / ETS family ...Protein C-ets-1, pointed domain / Transforming protein C-ets / Ets1, N-terminal flanking region of Ets domain / Ets1 N-terminal flanking region of Ets domain / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 1. / ETS family / Ets-domain signature 2. / Ets domain / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / Sterile alpha motif/pointed domain superfamily / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
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データ登録者 | Shiina, M. / Hamada, K. / Ogata, K. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2015 タイトル: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. 著者: Shiina, M. / Hamada, K. / Inoue-Bungo, T. / Shimamura, M. / Uchiyama, A. / Baba, S. / Sato, K. / Yamamoto, M. / Ogata, K. |
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履歴 | 登録 | 2014年4月21日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2014年8月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月22日 | Group: Refinement description / カテゴリ: software |
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改定 1.2 | 2022年8月24日 | Group: Database references / カテゴリ: citation / database_2 Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2023年11月8日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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