Entry Database : PDB / ID : 3vga Structure visualization Downloads & linksTitle Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 3.1 A resolution ComponentsAdenosine receptor A2a antibody fab fragment heavy chain antibody fab fragment light chain DetailsKeywords SIGNALING PROTEIN / 7 transmembrane receptor / SIGNAL TRANSDUCTIONFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / sensory perception / positive regulation of urine volume ... positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / sensory perception / positive regulation of urine volume / NGF-independant TRKA activation / Surfactant metabolism / synaptic transmission, dopaminergic / : / inhibitory postsynaptic potential / negative regulation of vascular permeability / synaptic transmission, cholinergic / type 5 metabotropic glutamate receptor binding / positive regulation of glutamate secretion / blood circulation / response to caffeine / intermediate filament / eating behavior / presynaptic active zone / alpha-actinin binding / membrane depolarization / regulation of calcium ion transport / asymmetric synapse / axolemma / : / cellular defense response / prepulse inhibition / phagocytosis / response to amphetamine / presynaptic modulation of chemical synaptic transmission / excitatory postsynaptic potential / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / regulation of mitochondrial membrane potential / synaptic transmission, glutamatergic / positive regulation of long-term synaptic potentiation / locomotory behavior / central nervous system development / astrocyte activation / positive regulation of synaptic transmission, GABAergic / positive regulation of protein secretion / apoptotic signaling pathway / positive regulation of apoptotic signaling pathway / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / negative regulation of inflammatory response / vasodilation / blood coagulation / cell-cell signaling / presynaptic membrane / G alpha (s) signalling events / postsynaptic membrane / negative regulation of neuron apoptotic process / calmodulin binding / response to xenobiotic stimulus / inflammatory response / negative regulation of cell population proliferation / neuronal cell body / glutamatergic synapse / lipid binding / apoptotic process / dendrite / protein-containing complex binding / regulation of DNA-templated transcription / enzyme binding / identical protein binding / membrane / plasma membrane Similarity search - Function Adenosine A2A receptor / Adenosine receptor / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) ... Adenosine A2A receptor / Adenosine receptor / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulins / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.1 Å DetailsAuthors Hino, T. / Arakawa, T. / Iwanari, H. / Yurugi-Kobayashi, T. / Ikeda-Suno, C. / Nakada-Nakura, Y. / Kusano-Arai, O. / Weyand, S. / Shimamura, T. / Nomura, N. ...Hino, T. / Arakawa, T. / Iwanari, H. / Yurugi-Kobayashi, T. / Ikeda-Suno, C. / Nakada-Nakura, Y. / Kusano-Arai, O. / Weyand, S. / Shimamura, T. / Nomura, N. / Cameron, A.D. / Kobayashi, T. / Hamakubo, T. / Iwata, S. / Murata, T. CitationJournal : Nature / Year : 2012Title : G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibodyAuthors: Hino, T. / Arakawa, T. / Iwanari, H. / Yurugi-Kobayashi, T. / Ikeda-Suno, C. / Nakada-Nakura, Y. / Kusano-Arai, O. / Weyand, S. / Shimamura, T. / Nomura, N. / Cameron, A.D. / Kobayashi, T. / ... Authors : Hino, T. / Arakawa, T. / Iwanari, H. / Yurugi-Kobayashi, T. / Ikeda-Suno, C. / Nakada-Nakura, Y. / Kusano-Arai, O. / Weyand, S. / Shimamura, T. / Nomura, N. / Cameron, A.D. / Kobayashi, T. / Hamakubo, T. / Iwata, S. / Murata, T. History Deposition Aug 4, 2011 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 1, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Feb 15, 2012 Group : Database referencesRevision 1.2 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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