RUNX2 regulates chondrocyte maturation / response to denervation involved in regulation of muscle adaptation / negative regulation of myotube differentiation / peptidyl-lysine deacetylation / positive regulation of protein sumoylation / regulation of protein binding / negative regulation of transcription by competitive promoter binding / protein deacetylation / cardiac muscle hypertrophy in response to stress / positive regulation of MHC class II biosynthetic process ...RUNX2 regulates chondrocyte maturation / response to denervation involved in regulation of muscle adaptation / negative regulation of myotube differentiation / peptidyl-lysine deacetylation / positive regulation of protein sumoylation / regulation of protein binding / negative regulation of transcription by competitive promoter binding / protein deacetylation / cardiac muscle hypertrophy in response to stress / positive regulation of MHC class II biosynthetic process / histone deacetylase / protein lysine deacetylase activity / negative regulation of glycolytic process / SUMO transferase activity / negative regulation of gene expression, epigenetic / histone deacetylase activity / intercellular bridge / type I interferon-mediated signaling pathway / B cell activation / Notch-HLH transcription pathway / potassium ion binding / RUNX3 regulates p14-ARF / histone deacetylase complex / protein sumoylation / transcription repressor complex / SUMOylation of chromatin organization proteins / response to interleukin-1 / B cell differentiation / SUMOylation of intracellular receptors / negative regulation of DNA-binding transcription factor activity / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / positive regulation of DNA-binding transcription factor activity / histone deacetylase binding / RNA polymerase II transcription regulator complex / nervous system development / DNA-binding transcription factor binding / RNA polymerase II-specific DNA-binding transcription factor binding / Ras protein signal transduction / molecular adaptor activity / nuclear speck / chromatin remodeling / inflammatory response / RNA polymerase II cis-regulatory region sequence-specific DNA binding / positive regulation of cell population proliferation / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
DNA-bindingproteinRFXANK / Ankyrin repeat family A protein 1 / Regulatory factor X subunit B / RFX-B / Regulatory factor X- ...Ankyrin repeat family A protein 1 / Regulatory factor X subunit B / RFX-B / Regulatory factor X-associated ankyrin-containing protein
Mass: 18907.254 Da / Num. of mol.: 1 / Fragment: UNP residues 90-260 / Mutation: R199H Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: RFXANK, ANKRA1, RFXB / Plasmid: pET28-MHL / Production host: Escherichia coli (E. coli) / Strain (production host): BL21-V2R-pRARE2 / References: UniProt: O14593
#2: Protein/peptide
Histonedeacetylase4 / HD4
Mass: 1796.113 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: synthetic peptide / Source: (synth.) Homo sapiens (human) / References: UniProt: P56524, histone deacetylase
Resolution: 1.85→39.86 Å / Cor.coef. Fo:Fc: 0.946 / Cor.coef. Fo:Fc free: 0.92 / WRfactor Rfree: 0.206 / WRfactor Rwork: 0.172 / Occupancy max: 1 / Occupancy min: 0.5 / SU B: 5.718 / SU ML: 0.078 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 0.121 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED. Arp/warp, coot and the molprobity server were also used during refinement. Residues 110 through 116 of chain A ...Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED. Arp/warp, coot and the molprobity server were also used during refinement. Residues 110 through 116 of chain A are poorly defined by electron density.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2215
935
5 %
RANDOM
Rwork
0.1866
-
-
-
obs
0.1883
18636
99.86 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK
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