Crystal Structure of Anthrax Protective Antigen (Membrane Insertion Loop Deleted) to 1.7-A resolution
要素
Protective antigen
キーワード
protein transport / toxin
機能・相同性
機能・相同性情報
positive regulation of apoptotic process in another organism / host cell cytosol / negative regulation of MAPK cascade / Uptake and function of anthrax toxins / host cell endosome membrane / protein homooligomerization / toxin activity / host cell plasma membrane / extracellular region / identical protein binding ...positive regulation of apoptotic process in another organism / host cell cytosol / negative regulation of MAPK cascade / Uptake and function of anthrax toxins / host cell endosome membrane / protein homooligomerization / toxin activity / host cell plasma membrane / extracellular region / identical protein binding / membrane / metal ion binding 類似検索 - 分子機能
THE CLOSEST DATABASE REFERENCE TO THE CRYSTALLIZED SEQUENCE CORRESPONDS TO UNP ENTRY P13423, WHICH ...THE CLOSEST DATABASE REFERENCE TO THE CRYSTALLIZED SEQUENCE CORRESPONDS TO UNP ENTRY P13423, WHICH CONTAINS A PRESEQUENCE THAT IS NOT INCLUDED IN NATURAL ANTHRAX PA, NOR WAS A PART OF THE PROTEIN CRYSTALLIZED. THE RESIDUE NUMBERS IN THIS STRUCTURE CONFORM TO THE SEQUENCE FOR PDB ACCESSION CODE 1ACC. TO CLARIFY IN TERMS OF UNP SEQUENCE, THE MUTATIONS MADE WERE V332P AND H333G.