Entry Database : PDB / ID : 3qbt Structure visualization Downloads & linksTitle Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp ComponentsInositol polyphosphate 5-phosphatase OCRL-1 Ras-related protein Rab-8A DetailsKeywords PROTEIN TRANSPORT/HYDROLASE / Protein transport / vesicular trafficking / GTPase / Lowe syndrome / immunoglobulin fold / Rab8a / OCRL1 / endocytosis / clathrin / APPL1 / phosphoinositide / ASH / RhoGAP / PROTEIN TRANSPORT-HYDROLASE complexFunction / homology Function and homology informationFunction Domain/homology Component
phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / neurotransmitter receptor transport to postsynaptic membrane / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / Golgi vesicle fusion to target membrane / Synthesis of IP2, IP, and Ins in the cytosol / vesicle-mediated transport in synapse / regulation of protein transport / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase ... phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / neurotransmitter receptor transport to postsynaptic membrane / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / Golgi vesicle fusion to target membrane / Synthesis of IP2, IP, and Ins in the cytosol / vesicle-mediated transport in synapse / regulation of protein transport / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase / VxPx cargo-targeting to cilium / inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase / inositol-1,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity / phosphoinositide 5-phosphatase / Synthesis of PIPs at the Golgi membrane / neurotransmitter receptor transport, endosome to postsynaptic membrane / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity / phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity / RAB geranylgeranylation / myosin V binding / phosphatidylinositol dephosphorylation / trans-Golgi network transport vesicle / Golgi stack / membrane organization / RAB GEFs exchange GTP for GDP on RABs / phosphatidylinositol biosynthetic process / endocytic recycling / protein localization to cilium / non-motile cilium / vesicle docking involved in exocytosis / TBC/RABGAPs / clathrin-coated vesicle / ciliary membrane / ciliary base / Golgi-associated vesicle / Golgi Associated Vesicle Biogenesis / Synthesis of IP3 and IP4 in the cytosol / RHOJ GTPase cycle / Golgi organization / exocytosis / Synthesis of PIPs at the plasma membrane / protein secretion / photoreceptor outer segment / cilium assembly / RAC3 GTPase cycle / clathrin-coated pit / phagocytic vesicle / Anchoring of the basal body to the plasma membrane / centriole / GTPase activator activity / protein tyrosine kinase binding / axonogenesis / small monomeric GTPase / ciliary basal body / trans-Golgi network membrane / regulation of autophagy / protein localization to plasma membrane / Translocation of SLC2A4 (GLUT4) to the plasma membrane / regulation of long-term neuronal synaptic plasticity / trans-Golgi network / lipid metabolic process / cilium / small GTPase binding / autophagy / cellular response to insulin stimulus / recycling endosome membrane / phagocytic vesicle membrane / GDP binding / Regulation of PLK1 Activity at G2/M Transition / synaptic vesicle / Clathrin-mediated endocytosis / midbody / early endosome membrane / in utero embryonic development / dendritic spine / postsynaptic density / early endosome / lysosome / endosome membrane / endosome / Golgi membrane / GTPase activity / centrosome / neuronal cell body / glutamatergic synapse / GTP binding / signal transduction / extracellular exosome / membrane / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / : / Inositol polyphosphate-related phosphatase ... Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / : / Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues / ARF-like small GTPases; ARF, ADP-ribosylation factor / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / small GTPase Rab1 family profile. / Endonuclease/exonuclease/phosphatase superfamily / Rho GTPase activation protein / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Ras-related protein Rab-8A / Inositol polyphosphate 5-phosphatase OCRL Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Hou, X. / Hagemann, N. / Schoebel, S. / Blankenfeldt, W. / Goody, R.S. / Erdmann, K.S. / Itzen, A. CitationJournal : Embo J. / Year : 2011Title : A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.Authors : Hou, X. / Hagemann, N. / Schoebel, S. / Blankenfeldt, W. / Goody, R.S. / Erdmann, K.S. / Itzen, A. History Deposition Jan 14, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 23, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Feb 29, 2012 Group : Database referencesRevision 1.3 Sep 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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