登録情報 | データベース: PDB / ID: 3qbt |
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タイトル | Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp |
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要素 | - Inositol polyphosphate 5-phosphatase OCRL-1
- Ras-related protein Rab-8A
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キーワード | PROTEIN TRANSPORT/HYDROLASE / Protein transport / vesicular trafficking / GTPase (GTPアーゼ) / Lowe syndrome / immunoglobulin fold / Rab8a / OCRL1 / endocytosis (エンドサイトーシス) / clathrin (クラスリン) / APPL1 / phosphoinositide (ホスファチジルイノシトール) / ASH / RhoGAP / PROTEIN TRANSPORT-HYDROLASE complex |
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機能・相同性 | 機能・相同性情報
phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / neurotransmitter receptor transport to postsynaptic membrane / Golgi vesicle fusion to target membrane / Synthesis of IP2, IP, and Ins in the cytosol / vesicle-mediated transport in synapse / regulation of protein transport / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase ...phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / neurotransmitter receptor transport to postsynaptic membrane / Golgi vesicle fusion to target membrane / Synthesis of IP2, IP, and Ins in the cytosol / vesicle-mediated transport in synapse / regulation of protein transport / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase / VxPx cargo-targeting to cilium / inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity / ホスファチジルイノシトール-3,4,5-三リン酸 5-ホスファターゼ / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity / inositol-1,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity / neurotransmitter receptor transport, endosome to postsynaptic membrane / ホスホイノシチド-5-ホスファターゼ / phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol dephosphorylation / ゴルジ体 / RAB geranylgeranylation / myosin V binding / vesicle docking involved in exocytosis / membrane organization / regulation of exocytosis / trans-Golgi network transport vesicle / RAB GEFs exchange GTP for GDP on RABs / protein localization to cilium / phosphatidylinositol biosynthetic process / non-motile cilium / endocytic recycling / TBC/RABGAPs / ciliary membrane / クラスリン / ciliary base / Golgi-associated vesicle / Golgi Associated Vesicle Biogenesis / RHOJ GTPase cycle / Golgi organization / Synthesis of IP3 and IP4 in the cytosol / Synthesis of PIPs at the plasma membrane / protein secretion / cilium assembly / photoreceptor outer segment / RAC3 GTPase cycle / phagocytic vesicle / クラスリン / Anchoring of the basal body to the plasma membrane / protein tyrosine kinase binding / 中心小体 / GTPase activator activity / 軸索誘導 / 低分子量GTPアーゼ / trans-Golgi network membrane / ciliary basal body / regulation of autophagy / Translocation of SLC2A4 (GLUT4) to the plasma membrane / protein localization to plasma membrane / regulation of long-term neuronal synaptic plasticity / ゴルジ体 / 繊毛 / lipid metabolic process / small GTPase binding / オートファジー / cellular response to insulin stimulus / recycling endosome membrane / phagocytic vesicle membrane / GDP binding / Regulation of PLK1 Activity at G2/M Transition / シナプス小胞 / Clathrin-mediated endocytosis / midbody / early endosome membrane / in utero embryonic development / 樹状突起スパイン / postsynaptic density / リソソーム / エンドソーム / endosome membrane / エンドソーム / ゴルジ体 / GTPase activity / 中心体 / neuronal cell body / glutamatergic synapse / GTP binding / シグナル伝達 / extracellular exosome / 生体膜 / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues ...Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues / ARF-like small GTPases; ARF, ADP-ribosylation factor / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / small GTPase Rab1 family profile. / Endonuclease/exonuclease/phosphatase superfamily / Rho GTPase activation protein / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / 低分子量GTPアーゼ / 低分子量GTPアーゼ / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / 抗体 / Immunoglobulin-like fold / Immunoglobulin-like / サンドイッチ / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Ras-related protein Rab-8A / Inositol polyphosphate 5-phosphatase OCRL類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Hou, X. / Hagemann, N. / Schoebel, S. / Blankenfeldt, W. / Goody, R.S. / Erdmann, K.S. / Itzen, A. |
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引用 | ジャーナル: Embo J. / 年: 2011 タイトル: A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. 著者: Hou, X. / Hagemann, N. / Schoebel, S. / Blankenfeldt, W. / Goody, R.S. / Erdmann, K.S. / Itzen, A. |
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履歴 | 登録 | 2011年1月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2011年3月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2012年2月29日 | Group: Database references |
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改定 1.3 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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