登録情報 | データベース: PDB / ID: 3q49 |
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タイトル | Crystal structure of the TPR domain of CHIP complexed with Hsp70-C peptide |
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要素 | - Hsp70-C peptide
- STIP1 homology and U box-containing protein 1
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キーワード | LIGASE/CHAPERONE / E3 ubiquitin ligase / LIGASE-CHAPERONE complex |
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機能・相同性 | 機能・相同性情報
positive regulation of chaperone-mediated protein complex assembly / Downregulation of TGF-beta receptor signaling / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / positive regulation of endoribonuclease activity / denatured protein binding / Regulation of PTEN stability and activity / Regulation of RUNX2 expression and activity ...positive regulation of chaperone-mediated protein complex assembly / Downregulation of TGF-beta receptor signaling / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / positive regulation of endoribonuclease activity / denatured protein binding / Regulation of PTEN stability and activity / Regulation of RUNX2 expression and activity / ubiquitin conjugating enzyme complex / cellular heat acclimation / positive regulation of ERAD pathway / death receptor agonist activity / negative regulation of inclusion body assembly / Viral RNP Complexes in the Host Cell Nucleus / positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of mitophagy / C3HC4-type RING finger domain binding / positive regulation of smooth muscle cell apoptotic process / positive regulation of microtubule nucleation / ATP-dependent protein disaggregase activity / nuclear inclusion body / Antigen processing: Ubiquitination & Proteasome degradation / misfolded protein binding / regulation of mitotic spindle assembly / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of tumor necrosis factor-mediated signaling pathway / R-SMAD binding / transcription regulator inhibitor activity / cellular response to misfolded protein / aggresome / protein folding chaperone complex / positive regulation of ubiquitin-protein transferase activity / lysosomal transport / ubiquitin-ubiquitin ligase activity / chaperone-mediated autophagy / cellular response to steroid hormone stimulus / protein quality control for misfolded or incompletely synthesized proteins / TPR domain binding / protein monoubiquitination / negative regulation of smooth muscle cell apoptotic process / mRNA catabolic process / protein K63-linked ubiquitination / positive regulation of proteolysis / regulation of protein ubiquitination / chaperone cofactor-dependent protein refolding / protein maturation / HSF1-dependent transactivation / response to unfolded protein / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / chaperone-mediated protein complex assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / cellular response to unfolded protein / protein autoubiquitination / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / ERAD pathway / ubiquitin ligase complex / ATP metabolic process / endoplasmic reticulum unfolded protein response / inclusion body / negative regulation of protein ubiquitination / protein folding chaperone / heat shock protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / Hsp70 protein binding / centriole / positive regulation of RNA splicing / positive regulation of erythrocyte differentiation / negative regulation of transforming growth factor beta receptor signaling pathway / positive regulation of protein ubiquitination / negative regulation of protein binding / positive regulation of interleukin-8 production / AUF1 (hnRNP D0) binds and destabilizes mRNA / response to ischemia / G protein-coupled receptor binding / ATP-dependent protein folding chaperone / kinase binding / Hsp90 protein binding / RING-type E3 ubiquitin transferase / PKR-mediated signaling / negative regulation of cell growth / histone deacetylase binding / Z disc / protein polyubiquitination / ubiquitin-protein transferase activity / transcription corepressor activity / disordered domain specific binding / MAPK cascade / ubiquitin protein ligase activity / unfolded protein binding / virus receptor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein folding / cellular response to hypoxia / positive regulation of NF-kappaB transcription factor activity / protein-macromolecule adaptor activity / protein-folding chaperone binding / cellular response to oxidative stress類似検索 - 分子機能 CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. ...CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Tetratricopeptide repeat domain / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / ATPase, nucleotide binding domain / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type / Mainly Alpha類似検索 - ドメイン・相同性 Heat shock 70 kDa protein 1A / E3 ubiquitin-protein ligase CHIP類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.543 Å |
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データ登録者 | Wang, L. / Chen, L. / Wu, J.W. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2011 タイトル: Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP). 著者: Wang, L. / Liu, Y.T. / Hao, R. / Chen, L. / Chang, Z. / Wang, H.R. / Wang, Z.X. / Wu, J.W. |
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履歴 | 登録 | 2010年12月23日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2011年3月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年11月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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