Repressor of RNA polymerase III transcription MAF1 homolog
Keywords
TRANSCRIPTION / RNA-Pol III transcriptional repressor / RNA-Pol III
Function / homology
Function and homology information
intracellular anatomical structure / negative regulation of transcription by RNA polymerase III / RNA polymerase III core binding / RNA polymerase III type 1 promoter sequence-specific DNA binding / RNA polymerase III type 2 promoter sequence-specific DNA binding / inhibitory synapse / RNA polymerase III type 3 promoter sequence-specific DNA binding / GABA receptor binding / negative regulation of transcription by RNA polymerase I / Regulation of PTEN gene transcription ...intracellular anatomical structure / negative regulation of transcription by RNA polymerase III / RNA polymerase III core binding / RNA polymerase III type 1 promoter sequence-specific DNA binding / RNA polymerase III type 2 promoter sequence-specific DNA binding / inhibitory synapse / RNA polymerase III type 3 promoter sequence-specific DNA binding / GABA receptor binding / negative regulation of transcription by RNA polymerase I / Regulation of PTEN gene transcription / axon / intracellular membrane-bounded organelle / dendrite / nucleolus / perinuclear region of cytoplasm / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function
Repressor of RNA polymerase III transcription Maf1 / Repressor of RNA polymerase III transcription Maf1 / Repressor of RNA polymerase III transcription Maf1 superfamily / Maf1 regulator / Protein Transport Mog1p; Chain A / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology
Journal: Cell / Year: 2010 Title: Molecular basis of RNA polymerase III transcription repression by Maf1. Authors: Alessandro Vannini / Rieke Ringel / Anselm G Kusser / Otto Berninghausen / George A Kassavetis / Patrick Cramer / Abstract: RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal ...RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal structure of Maf1 and cryo-electron microscopic structures of Pol III, an active Pol III-DNA-RNA complex, and a repressive Pol III-Maf1 complex. Binding of DNA and RNA causes ordering of the Pol III-specific subcomplex C82/34/31 that is required for transcription initiation. Maf1 binds the Pol III clamp and rearranges C82/34/31 at the rim of the active center cleft. This impairs recruitment of Pol III to a complex of promoter DNA with the initiation factors Brf1 and TBP and thus prevents closed complex formation. Maf1 does however not impair binding of a DNA-RNA scaffold and RNA synthesis. These results explain how Maf1 specifically represses transcription initiation from Pol III promoters and indicate that Maf1 also prevents reinitiation by binding Pol III during transcription elongation.
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