登録情報 | データベース: PDB / ID: 3lw2 |
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タイトル | Mouse Plasminogen Activator Inhibitor-1 (PAI-1) |
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要素 | Plasminogen activator inhibitor 1 |
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キーワード | HYDROLASE INHIBITOR / latent mouse plasminogen activator inhibitor-1 (PAI-1) / Glycoprotein (糖タンパク質) / Plasminogen activation |
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機能・相同性 | 機能・相同性情報
positive regulation of epithelium regeneration / Dissolution of Fibrin Clot / ECM proteoglycans / positive regulation of leukotriene production involved in inflammatory response / cellular response to xenobiotic stimulus => GO:0071466 / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / positive regulation of coagulation / negative regulation of smooth muscle cell migration / クロム親和性細胞 ...positive regulation of epithelium regeneration / Dissolution of Fibrin Clot / ECM proteoglycans / positive regulation of leukotriene production involved in inflammatory response / cellular response to xenobiotic stimulus => GO:0071466 / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / positive regulation of coagulation / negative regulation of smooth muscle cell migration / クロム親和性細胞 / negative regulation of vascular wound healing / Platelet degranulation / positive regulation of odontoblast differentiation / positive regulation of keratinocyte migration / negative regulation of cell adhesion mediated by integrin / negative regulation of endopeptidase activity / negative regulation of plasminogen activation / regulation of signaling receptor activity / positive regulation of monocyte chemotaxis / female gonad development / positive regulation of calcium ion import / ヘイフリック限界 / positive regulation of collagen biosynthetic process / positive regulation of blood coagulation / cellular response to interleukin-1 / regulation of angiogenesis / negative regulation of fibrinolysis / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / cellular response to transforming growth factor beta stimulus / negative regulation of cell migration / placenta development / positive regulation of interleukin-8 production / serine-type endopeptidase inhibitor activity / positive regulation of inflammatory response / positive regulation of receptor-mediated endocytosis / positive regulation of angiogenesis / positive regulation of fibroblast proliferation / regulation of cell population proliferation / collagen-containing extracellular matrix / cellular response to lipopolysaccharide / protease binding / defense response to Gram-negative bacterium / negative regulation of gene expression / signaling receptor binding / positive regulation of gene expression / extracellular space / extracellular exosome / extracellular region / 細胞質類似検索 - 分子機能 Antithrombin; Chain I, domain 2 / Antithrombin, subunit I, domain 2 / Alpha-1-antitrypsin; domain 1 / Alpha-1-antitrypsin, domain 1 / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / セルピン / Serpin domain / セルピン ...Antithrombin; Chain I, domain 2 / Antithrombin, subunit I, domain 2 / Alpha-1-antitrypsin; domain 1 / Alpha-1-antitrypsin, domain 1 / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / セルピン / Serpin domain / セルピン / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) / SERine Proteinase INhibitors / Roll / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.93 Å |
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データ登録者 | Dewilde, M. / Van De Craen, B. / Compernolle, G. / Madsen, J.B. / Strelkov, S.V. / Gils, A. / Declerck, P.J. |
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引用 | ジャーナル: J.Struct.Biol. / 年: 2010 タイトル: Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences. 著者: Dewilde, M. / Van De Craen, B. / Compernolle, G. / Madsen, J.B. / Strelkov, S. / Gils, A. / Declerck, P.J. |
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履歴 | 登録 | 2010年2月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年4月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2013年6月19日 | Group: Database references |
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改定 1.3 | 2017年11月8日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2023年9月6日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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