登録情報 | データベース: PDB / ID: 3ktr |
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タイトル | Structural basis of ataxin-2 recognition by poly(A)-binding protein |
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要素 | - Ataxin-2
- Polyadenylate-binding protein 1
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キーワード | PROTEIN BINDING / protein-protein complex / Acetylation / Alternative splicing / Cytoplasm / Methylation / mRNA processing / mRNA splicing / Nucleus / Phosphoprotein / RNA-binding / Spliceosome / Neurodegeneration / Parkinsonism / Polymorphism / Spinocerebellar ataxia / Triplet repeat expansion |
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機能・相同性 | 機能・相同性情報
mCRD-mediated mRNA stability complex / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / RNA metabolic process / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / translation activator activity / RNA transport / CRD-mediated mRNA stabilization / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / Deadenylation of mRNA / poly(A) binding ...mCRD-mediated mRNA stability complex / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / RNA metabolic process / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / translation activator activity / RNA transport / CRD-mediated mRNA stabilization / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / Deadenylation of mRNA / poly(A) binding / negative regulation of receptor internalization / M-decay: degradation of maternal mRNAs by maternally stored factors / positive regulation of cytoplasmic translation / regulatory ncRNA-mediated gene silencing / mRNA stabilization / P-body assembly / epidermal growth factor receptor binding / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / poly(U) RNA binding / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / Translation initiation complex formation / cell leading edge / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / L13a-mediated translational silencing of Ceruloplasmin expression / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / catalytic step 2 spliceosome / stress granule assembly / mRNA 3'-UTR binding / AUF1 (hnRNP D0) binds and destabilizes mRNA / trans-Golgi network / mRNA splicing, via spliceosome / Regulation of expression of SLITs and ROBOs / cytoplasmic ribonucleoprotein granule / cytoplasmic stress granule / lamellipodium / regulation of translation / ribonucleoprotein complex / focal adhesion / mRNA binding / perinuclear region of cytoplasm / Golgi apparatus / RNA binding / extracellular exosome / nucleus / membrane / cytosol / cytoplasm類似検索 - 分子機能 LsmAD domain / Ataxin2-like / LsmAD domain / LsmAD / Ataxin 2, SM domain / Ataxin 2 SM domain / Ataxin-2, C-terminal / Ataxin-2 C-terminal region / c-terminal domain of poly(a) binding protein / c-terminal domain of poly(a) binding protein ...LsmAD domain / Ataxin2-like / LsmAD domain / LsmAD / Ataxin 2, SM domain / Ataxin 2 SM domain / Ataxin-2, C-terminal / Ataxin-2 C-terminal region / c-terminal domain of poly(a) binding protein / c-terminal domain of poly(a) binding protein / : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / Polyadenylate-binding protein/Hyperplastic disc protein / PABC (PABP) domain / MLLE domain / RNA recognition motif domain, eukaryote / RNA recognition motif / : / Sm domain profile. / LSM domain superfamily / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 : / Polyadenylate-binding protein 1 / Ataxin-2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Kozlov, G. / Gehring, K. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2010 タイトル: Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. 著者: Kozlov, G. / Safaee, N. / Rosenauer, A. / Gehring, K. |
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履歴 | 登録 | 2009年11月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年2月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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