登録情報 | データベース: PDB / ID: 3k9m |
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タイトル | Cathepsin B in complex with stefin A |
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要素 | |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Disulfide bond / Glycoprotein / Lysosome / Protease / Thiol protease / Zymogen / Thiol protease inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
cathepsin B / negative regulation of peptidase activity / peptidase inhibitor complex / Formation of the cornified envelope / peptide cross-linking / cornified envelope / thyroid hormone generation / endolysosome lumen / cellular response to thyroid hormone stimulus / Trafficking and processing of endosomal TLR ...cathepsin B / negative regulation of peptidase activity / peptidase inhibitor complex / Formation of the cornified envelope / peptide cross-linking / cornified envelope / thyroid hormone generation / endolysosome lumen / cellular response to thyroid hormone stimulus / Trafficking and processing of endosomal TLR / proteoglycan binding / Assembly of collagen fibrils and other multimeric structures / cysteine-type endopeptidase inhibitor activity / Collagen degradation / decidualization / collagen catabolic process / cysteine-type peptidase activity / keratinocyte differentiation / epithelial cell differentiation / collagen binding / MHC class II antigen presentation / proteolysis involved in protein catabolic process / negative regulation of proteolysis / cell-cell adhesion / melanosome / peptidase activity / regulation of apoptotic process / collagen-containing extracellular matrix / protease binding / ficolin-1-rich granule lumen / lysosome / symbiont entry into host cell / apical plasma membrane / external side of plasma membrane / cysteine-type endopeptidase activity / Neutrophil degranulation / perinuclear region of cytoplasm / proteolysis / extracellular space / extracellular exosome / extracellular region / nucleoplasm / cytoplasm / cytosol類似検索 - 分子機能 Proteinase inhibitor I25A, stefin / Peptidase C1A, propeptide / Peptidase family C1 propeptide / Proteinase inhibitor I25, cystatin, conserved site / Cysteine proteases inhibitors signature. / Cystatin domain / Cystatin-like domain / Cystatin domain / Nuclear Transport Factor 2; Chain: A, - #10 / Cystatin superfamily ...Proteinase inhibitor I25A, stefin / Peptidase C1A, propeptide / Peptidase family C1 propeptide / Proteinase inhibitor I25, cystatin, conserved site / Cysteine proteases inhibitors signature. / Cystatin domain / Cystatin-like domain / Cystatin domain / Nuclear Transport Factor 2; Chain: A, - #10 / Cystatin superfamily / : / Cysteine peptidase, asparagine active site / Eukaryotic thiol (cysteine) proteases asparagine active site. / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / Nuclear Transport Factor 2; Chain: A, / Papain-like cysteine peptidase superfamily / Roll / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.61 Å |
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データ登録者 | Renko, M. / Turk, D. |
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引用 | ジャーナル: Febs J. / 年: 2010 タイトル: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft 著者: Renko, M. / Pozgan, U. / Majera, D. / Turk, D. |
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履歴 | 登録 | 2009年10月16日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2009年11月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2011年10月5日 | Group: Database references / Structure summary |
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改定 1.3 | 2017年11月1日 | Group: Advisory / Refinement description カテゴリ: pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / software |
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改定 1.4 | 2023年11月1日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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