- PDB-3hxi: Crystal structure of Schistosome eIF4E complexed with m7GpppG and... -
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基本情報
登録情報
データベース: PDB / ID: 3hxi
タイトル
Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP
要素
Eukaryotic Translation Initiation 4E
Eukaryotic translation initiation factor 4E-binding protein 1
キーワード
TRANSLATION / protein-mRNA cap complex / Acetylation / Phosphoprotein / Protein synthesis inhibitor / Translation regulation
機能・相同性
機能・相同性情報
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4E binding / mTORC1-mediated signalling / TOR signaling / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / positive regulation of mitotic cell cycle / G1/S transition of mitotic cell cycle / negative regulation of translation ...Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4E binding / mTORC1-mediated signalling / TOR signaling / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / positive regulation of mitotic cell cycle / G1/S transition of mitotic cell cycle / negative regulation of translation / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
Eukaryotictranslationinitiationfactor4E-bindingprotein1 / eIF4E-binding protein 1 / 4E-BP1 / Phosphorylated heat- and acid-stable protein regulated by ...eIF4E-binding protein 1 / 4E-BP1 / Phosphorylated heat- and acid-stable protein regulated by insulin 1 / PHAS-I
解像度: 1.8→24 Å / Cor.coef. Fo:Fc: 0.946 / Cor.coef. Fo:Fc free: 0.917 / SU B: 3.461 / SU ML: 0.107 / 交差検証法: THROUGHOUT / ESU R: 0.175 / ESU R Free: 0.167 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.27158
1969
10.2 %
RANDOM
Rwork
0.21831
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obs
0.22355
17407
94.46 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: BABINET MODEL WITH MASK