- PDB-3fey: Crystal structure of the CBC-importin alpha complex. -
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基本情報
登録情報
データベース: PDB / ID: 3fey
タイトル
Crystal structure of the CBC-importin alpha complex.
要素
Importin subunit alpha-2
Nuclear cap-binding protein subunit 1
Nuclear cap-binding protein subunit 2
キーワード
TRANSLATION / PROTEIN TRANSPORT / Cap binding complex / importin alpha / nuclear transport / mRNA transport / Nucleus / Phosphoprotein / RNA-binding / Host-virus interaction
機能・相同性
機能・相同性情報
positive regulation of RNA binding / snRNA export from nucleus / nuclear cap binding complex / mRNA metabolic process / RNA cap binding complex / histone mRNA metabolic process / positive regulation of mRNA 3'-end processing / positive regulation of RNA export from nucleus / Sensing of DNA Double Strand Breaks / regulation of DNA recombination ...positive regulation of RNA binding / snRNA export from nucleus / nuclear cap binding complex / mRNA metabolic process / RNA cap binding complex / histone mRNA metabolic process / positive regulation of mRNA 3'-end processing / positive regulation of RNA export from nucleus / Sensing of DNA Double Strand Breaks / regulation of DNA recombination / cap-dependent translational initiation / Processing of Intronless Pre-mRNAs / snRNA binding / RNA cap binding / alternative mRNA splicing, via spliceosome / entry of viral genome into host nucleus through nuclear pore complex via importin / miRNA-mediated post-transcriptional gene silencing / primary miRNA processing / regulation of mRNA processing / SLBP independent Processing of Histone Pre-mRNAs / positive regulation of viral life cycle / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / regulatory ncRNA-mediated post-transcriptional gene silencing / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / RNA 7-methylguanosine cap binding / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex / Transport of Mature mRNA Derived from an Intronless Transcript / mRNA 3'-end processing / mRNA 3'-end processing / RNA catabolic process / mRNA cis splicing, via spliceosome / Transport of Mature mRNA derived from an Intron-Containing Transcript / Abortive elongation of HIV-1 transcript in the absence of Tat / positive regulation of mRNA splicing, via spliceosome / regulation of translational initiation / FGFR2 alternative splicing / RNA Polymerase II Transcription Termination / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / nuclear import signal receptor activity / DNA metabolic process / CaMK IV-mediated phosphorylation of CREB / Signaling by FGFR2 IIIa TM / nuclear localization sequence binding / NLS-bearing protein import into nucleus / Formation of the Early Elongation Complex / Formation of the HIV-1 Early Elongation Complex / mRNA Capping / spliceosomal complex assembly / mRNA Splicing - Minor Pathway / Processing of Capped Intron-Containing Pre-mRNA / RNA polymerase II transcribes snRNA genes / 7-methylguanosine mRNA capping / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / positive regulation of type I interferon production / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / mRNA export from nucleus / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events / mRNA Splicing - Major Pathway / RNA splicing / positive regulation of transcription elongation by RNA polymerase II / mRNA transcription by RNA polymerase II / ISG15 antiviral mechanism / histone deacetylase binding / Regulation of expression of SLITs and ROBOs / mRNA splicing, via spliceosome / protein import into nucleus / SARS-CoV-1 activates/modulates innate immune responses / host cell / snRNP Assembly / positive regulation of cell growth / nuclear membrane / defense response to virus / Estrogen-dependent gene expression / molecular adaptor activity / ribonucleoprotein complex / Golgi membrane / mRNA binding / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / mitochondrion / DNA binding / RNA binding / nucleoplasm / membrane / nucleus / cytosol / cytoplasm 類似検索 - 分子機能