登録情報 | データベース: PDB / ID: 3ewt |
---|
タイトル | Crystal Structure of calmodulin complexed with a peptide |
---|
要素 | - Calmodulin
- Tumor necrosis factor receptor superfamily member 6
|
---|
キーワード | CALCIUM BINDING PROTEIN / Calmodulin-peptide complex / Fas / death domain |
---|
機能・相同性 | 機能・相同性情報
Fas signaling pathway / cellular response to hyperoxia / FasL/ CD95L signaling / tumor necrosis factor receptor activity / CD95 death-inducing signaling complex / positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand ...Fas signaling pathway / cellular response to hyperoxia / FasL/ CD95L signaling / tumor necrosis factor receptor activity / CD95 death-inducing signaling complex / positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand / : / necroptotic signaling pathway / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / death-inducing signaling complex / CaM pathway / Cam-PDE 1 activation / Sodium/Calcium exchangers / motor neuron apoptotic process / Calmodulin induced events / regulation of synaptic vesicle endocytosis / Reduction of cytosolic Ca++ levels / TP53 Regulates Transcription of Death Receptors and Ligands / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Activation of Ca-permeable Kainate Receptor / Loss of phosphorylation of MECP2 at T308 / CREB1 phosphorylation through the activation of Adenylate Cyclase / PKA activation / RIPK1-mediated regulated necrosis / negative regulation of high voltage-gated calcium channel activity / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / positive regulation of cyclic-nucleotide phosphodiesterase activity / regulation of synaptic vesicle exocytosis / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / CLEC7A (Dectin-1) induces NFAT activation / regulation of stress-activated MAPK cascade / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / regulation of cardiac muscle cell action potential / Activation of RAC1 downstream of NMDARs / response to corticosterone / positive regulation of DNA binding / activation-induced cell death of T cells / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / Negative regulation of NMDA receptor-mediated neuronal transmission / nitric-oxide synthase binding / negative regulation of peptidyl-threonine phosphorylation / Synthesis of IP3 and IP4 in the cytosol / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / negative regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / RHO GTPases activate PAKs / : / Ion transport by P-type ATPases / Long-term potentiation / Uptake and function of anthrax toxins / Regulation of MECP2 expression and activity / Calcineurin activates NFAT / adenylate cyclase binding / catalytic complex / DARPP-32 events / detection of calcium ion / regulation of cardiac muscle contraction / regulation of ryanodine-sensitive calcium-release channel activity / Smooth Muscle Contraction / cellular response to interferon-beta / RHO GTPases activate IQGAPs / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / calcium channel inhibitor activity / phosphatidylinositol 3-kinase binding / eNOS activation / Protein methylation / enzyme regulator activity / activation of adenylate cyclase activity / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / Activation of AMPK downstream of NMDARs / extrinsic apoptotic signaling pathway / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / extrinsic apoptotic signaling pathway in absence of ligand / Ion homeostasis / : / titin binding / regulation of calcium-mediated signaling / positive regulation of protein autophosphorylation / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / response to amphetamine / substantia nigra development / adenylate cyclase activator activity / Ras activation upon Ca2+ influx through NMDA receptor / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / cellular response to amino acid starvation / FCERI mediated Ca+2 mobilization類似検索 - 分子機能 Fas receptor / Fas receptor, death domain / Fas receptor, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). ...Fas receptor / Fas receptor, death domain / Fas receptor, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / : / Death-like domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 Calmodulin-1 / Tumor necrosis factor receptor superfamily member 6 / Calmodulin-3類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
---|
手法 | X線回折 / 分子置換 / 解像度: 2.4 Å |
---|
データ登録者 | Jiang, T. / Cao, P. / Gong, Y. / Yu, H.J. / Gui, W.J. / Zhang, W.T. |
---|
引用 | ジャーナル: Acta Crystallogr.,Sect.D / 年: 2014 タイトル: Structural insights into the mechanism of calmodulin binding to death receptors. 著者: Cao, P. / Zhang, W. / Gui, W. / Dong, Y. / Jiang, T. / Gong, Y. |
---|
履歴 | 登録 | 2008年10月16日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2009年10月20日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2014年6月18日 | Group: Database references |
---|
改定 1.3 | 2020年1月1日 | Group: Database references / Source and taxonomy カテゴリ: citation / citation_author ...citation / citation_author / pdbx_entity_src_syn / struct_ref_seq_dif Item: _citation.country / _citation.journal_id_CSD ..._citation.country / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name / _pdbx_entity_src_syn.ncbi_taxonomy_id / _pdbx_entity_src_syn.organism_scientific / _struct_ref_seq_dif.details |
---|
改定 1.4 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|