登録情報 | データベース: PDB / ID: 3eu7 |
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タイトル | Crystal Structure of a PALB2 / BRCA2 complex |
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要素 | - 19meric peptide from Breast cancer type 2 susceptibility protein
- Partner and localizer of BRCA2
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キーワード | Transcription/antitumor Protein / WD40 domain / Beta Propeller / Protein-Peptide Complex / Fanconi anemia / Nucleus / Phosphoprotein / WD repeat / Disease mutation / DNA damage / DNA repair / Transcription-antitumor Protein COMPLEX |
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機能・相同性 | 機能・相同性情報
BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / mitotic recombination-dependent replication fork processing / establishment of protein localization to telomere / nuclear ubiquitin ligase complex / female gonad development / Impaired BRCA2 translocation to the nucleus / Impaired BRCA2 binding to SEM1 (DSS1) / histone H4 acetyltransferase activity / histone H3 acetyltransferase activity ...BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / mitotic recombination-dependent replication fork processing / establishment of protein localization to telomere / nuclear ubiquitin ligase complex / female gonad development / Impaired BRCA2 translocation to the nucleus / Impaired BRCA2 binding to SEM1 (DSS1) / histone H4 acetyltransferase activity / histone H3 acetyltransferase activity / post-anal tail morphogenesis / lateral element / regulation of DNA damage checkpoint / Impaired BRCA2 binding to PALB2 / male meiosis I / telomere maintenance via recombination / HDR through MMEJ (alt-NHEJ) / gamma-tubulin binding / oocyte maturation / DNA repair complex / response to UV-C / Homologous DNA Pairing and Strand Exchange / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / inner cell mass cell proliferation / Impaired BRCA2 binding to RAD51 / hematopoietic stem cell proliferation / mesoderm development / centrosome duplication / Presynaptic phase of homologous DNA pairing and strand exchange / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / response to X-ray / embryonic organ development / somitogenesis / cellular response to ionizing radiation / positive regulation of mitotic cell cycle / secretory granule / regulation of cytokinesis / animal organ morphogenesis / double-strand break repair via homologous recombination / response to gamma radiation / nucleotide-excision repair / DNA damage response, signal transduction by p53 class mediator / HDR through Homologous Recombination (HRR) / brain development / Meiotic recombination / multicellular organism growth / KEAP1-NFE2L2 pathway / cellular senescence / double-strand break repair / Neddylation / single-stranded DNA binding / protease binding / spermatogenesis / chromosome, telomeric region / nuclear speck / apoptotic process / centrosome / negative regulation of apoptotic process / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / protein-containing complex / DNA binding / nucleoplasm / identical protein binding / nucleus / cytosol類似検索 - 分子機能 Partner and localiser of BRCA2, WD40 domain / Partner and localizer of BRCA2 / Partner and localizer of BRCA2 WD40 domain / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / : / : / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 ...Partner and localiser of BRCA2, WD40 domain / Partner and localizer of BRCA2 / Partner and localizer of BRCA2 WD40 domain / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / : / : / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 / Tower / BRCA2, helical / BRCA2, OB2 / BRCA2 TR2 domain / Tower / BRCA2 repeat / BRCA2, OB1 / Breast cancer type 2 susceptibility protein / BRCA2 repeat / BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 / BRCA2 repeat profile. / YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Nucleic acid-binding, OB-fold / Mainly Beta類似検索 - ドメイン・相同性 Breast cancer type 2 susceptibility protein / Partner and localizer of BRCA2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Oliver, A.W. / Pearl, L.H. |
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引用 | ジャーナル: Embo Rep. / 年: 2009 タイトル: Structural basis for recruitment of BRCA2 by PALB2 著者: Oliver, A.W. / Swift, S. / Lord, C.J. / Ashworth, A. / Pearl, L.H. |
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履歴 | 登録 | 2008年10月9日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2009年7月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.2 | 2014年2月5日 | Group: Derived calculations |
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改定 1.3 | 2014年11月12日 | Group: Other |
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改定 1.4 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.5 | 2024年10月16日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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