登録情報 | データベース: PDB / ID: 3eqt |
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タイトル | Crystal structure of human LGP2 C-terminal domain in complex with dsRNA |
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要素 | - 5'-R(*GP*CP*GP*CP*GP*CP*GP*C)-3'
- ATP-dependent RNA helicase DHX58
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キーワード | RNA BINDING PROTEIN/RNA / innate immunity / RIG-I-like helicases / viral RNA detection / LGP2-dsRNA complex / ATP-binding / Coiled coil / Cytoplasm / Helicase / Hydrolase / Immune response / Nucleotide-binding / Polymorphism / RNA-binding / RNA BINDING PROTEIN-RNA COMPLEX |
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機能・相同性 | 機能・相同性情報
positive regulation of MDA-5 signaling pathway / negative regulation of MDA-5 signaling pathway / negative regulation of RIG-I signaling pathway / positive regulation of RIG-I signaling pathway / negative regulation of type I interferon production / cytoplasmic pattern recognition receptor signaling pathway / regulation of innate immune response / positive regulation of type I interferon production / antiviral innate immune response / negative regulation of innate immune response ...positive regulation of MDA-5 signaling pathway / negative regulation of MDA-5 signaling pathway / negative regulation of RIG-I signaling pathway / positive regulation of RIG-I signaling pathway / negative regulation of type I interferon production / cytoplasmic pattern recognition receptor signaling pathway / regulation of innate immune response / positive regulation of type I interferon production / antiviral innate immune response / negative regulation of innate immune response / response to bacterium / DDX58/IFIH1-mediated induction of interferon-alpha/beta / response to virus / double-stranded RNA binding / RNA helicase activity / single-stranded RNA binding / RNA helicase / ATP hydrolysis activity / DNA binding / zinc ion binding / ATP binding / cytoplasm類似検索 - 分子機能 RIG-I-like receptor, C-terminal regulatory domain / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / RIG-I-like receptor, C-terminal / : / RIG-I receptor C-terminal domain / RIG-I-like receptor, C-terminal regulatory domain / RIG-I-like receptor, C-terminal domain superfamily / C-terminal domain of RIG-I / RIG-I-like receptor (RLR) C-terminal regulatory (CTR) domain profile. / Helicase/UvrB, N-terminal ...RIG-I-like receptor, C-terminal regulatory domain / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / RIG-I-like receptor, C-terminal / : / RIG-I receptor C-terminal domain / RIG-I-like receptor, C-terminal regulatory domain / RIG-I-like receptor, C-terminal domain superfamily / C-terminal domain of RIG-I / RIG-I-like receptor (RLR) C-terminal regulatory (CTR) domain profile. / Helicase/UvrB, N-terminal / Type III restriction enzyme, res subunit / Beta Complex / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2 Å |
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データ登録者 | Li, P. / Li, X. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2009 タイトル: The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA 著者: Li, X. / Ranjith-Kumar, C.T. / Brooks, M.T. / Dharmaiah, S. / Herr, A.B. / Kao, C. / Li, P. |
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履歴 | 登録 | 2008年10月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年3月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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