Entry | Database: PDB / ID: 3e0v |
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Title | Crystal structure of pyruvate kinase from Leishmania mexicana in complex with sulphate ions |
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Components | Pyruvate kinase |
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Keywords | TRANSFERASE / PYRUVATE / KINASE / NAD+ NADH / ADP / PHOSPHOENOLPYRUVATE / PEP / GLYCOLYSIS / TRYPANOSOMATID / LEISHMANIA / MEXICANA / Allosteric enzyme / Magnesium / Metal-binding |
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Function / homology | Function and homology information
pyruvate kinase / pyruvate kinase activity / potassium ion binding / cellular response to insulin stimulus / kinase activity / magnesium ion binding / ATP binding / cytoplasmSimilarity search - Function PK beta-barrel domain-like / M1 Pyruvate Kinase; Domain 3 / Pyruvate kinase, C-terminal domain / Pyruvate Kinase; Chain: A, domain 1 / Pyruvate kinase, active site / Pyruvate kinase active site signature. / Pyruvate kinase / Pyruvate kinase, barrel / Pyruvate kinase, insert domain superfamily / Pyruvate kinase, barrel domain ...PK beta-barrel domain-like / M1 Pyruvate Kinase; Domain 3 / Pyruvate kinase, C-terminal domain / Pyruvate Kinase; Chain: A, domain 1 / Pyruvate kinase, active site / Pyruvate kinase active site signature. / Pyruvate kinase / Pyruvate kinase, barrel / Pyruvate kinase, insert domain superfamily / Pyruvate kinase, barrel domain / Pyruvate kinase, C-terminal / Pyruvate kinase, C-terminal domain superfamily / Pyruvate kinase, alpha/beta domain / Pyruvate kinase-like, insert domain superfamily / Phosphoenolpyruvate-binding domains / Pyruvate kinase-like domain superfamily / Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily / TIM Barrel / Alpha-Beta Barrel / Beta Barrel / 3-Layer(aba) Sandwich / Mainly Beta / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_eukaryote.gif) Leishmania mexicana (eukaryote) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.3 Å |
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Authors | Tulloch, L.B. / Gillmore, L.A. / Walkinshaw, M.D. |
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Citation | Journal: J.Mol.Biol. / Year: 2008 Title: Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state. Authors: Tulloch, L.B. / Morgan, H.P. / Hannaert, V. / Michels, P.A. / Fothergill-Gilmore, L.A. / Walkinshaw, M.D. |
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History | Deposition | Aug 1, 2008 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 19, 2008 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Oct 20, 2021 | Group: Database references / Derived calculations / Category: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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Revision 1.3 | Aug 30, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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