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TitleSulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state.
Journal, issue, pagesJ. Mol. Biol., Vol. 383, Page 615-626, Year 2008
Publish dateAug 1, 2008 (structure data deposition date)
AuthorsTulloch, L.B. / Morgan, H.P. / Hannaert, V. / Michels, P.A. / Fothergill-Gilmore, L.A. / Walkinshaw, M.D.
External linksJ. Mol. Biol. / PubMed:18775437
MethodsX-ray diffraction
Resolution3.1 - 3.3 Å
Structure data

PDB-3e0v:
Crystal structure of pyruvate kinase from Leishmania mexicana in complex with sulphate ions
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-3e0w:
Crystal structure of pyruvate kinase from Leishmania mexicana
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • leishmania mexicana (eukaryote)
KeywordsTRANSFERASE / PYRUVATE / KINASE / NAD+ NADH / ADP / PHOSPHOENOLPYRUVATE / PEP / GLYCOLYSIS / TRYPANOSOMATID / LEISHMANIA / MEXICANA / Allosteric enzyme / Magnesium / Metal-binding

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