- PDB-3e0j: X-ray structure of the complex of regulatory subunits of human DN... -
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Basic information
Entry
Database: PDB / ID: 3e0j
Title
X-ray structure of the complex of regulatory subunits of human DNA polymerase delta
Components
DNA polymerase subunit delta-2
DNA polymerase subunit delta-3
Keywords
TRANSFERASE / DNA Polymerase Delta / p66 subunit / p50 subunit / human / DNA replication / DNA-directed DNA polymerase / Nucleotidyltransferase / Nucleus / Polymorphism / Phosphoprotein
Function / homology
Function and homology information
delta DNA polymerase complex / DNA synthesis involved in UV-damage excision repair / zeta DNA polymerase complex / Polymerase switching / Telomere C-strand (Lagging Strand) Synthesis / Processive synthesis on the lagging strand / Removal of the Flap Intermediate / Processive synthesis on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Polymerase switching on the C-strand of the telomere ...delta DNA polymerase complex / DNA synthesis involved in UV-damage excision repair / zeta DNA polymerase complex / Polymerase switching / Telomere C-strand (Lagging Strand) Synthesis / Processive synthesis on the lagging strand / Removal of the Flap Intermediate / Processive synthesis on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Polymerase switching on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / Removal of the Flap Intermediate from the C-strand / nucleotide-excision repair, DNA gap filling / DNA strand elongation involved in DNA replication / DNA synthesis involved in DNA repair / DNA biosynthetic process / PCNA-Dependent Long Patch Base Excision Repair / error-prone translesion synthesis / mismatch repair / Gap-filling DNA repair synthesis and ligation in GG-NER / Recognition of DNA damage by PCNA-containing replication complex / Termination of translesion DNA synthesis / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / DNA-templated DNA replication / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / protein-macromolecule adaptor activity / DNA replication / DNA-directed DNA polymerase activity / DNA binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function
OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #430 / Purple Acid Phosphatase; chain A, domain 2 - #50 / DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain / DNA polymerase delta subunit 3 / DNA polymerase delta subunit 3 superfamily / DNA polymerase subunit Cdc27 / DNA polymerase delta subunit, OB-fold domain / DNA polymerase delta subunit 2, C-terminal domain / DNA polymerase delta subunit OB-fold domain / DNA polymerase delta/II small subunit family ...OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #430 / Purple Acid Phosphatase; chain A, domain 2 - #50 / DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain / DNA polymerase delta subunit 3 / DNA polymerase delta subunit 3 superfamily / DNA polymerase subunit Cdc27 / DNA polymerase delta subunit, OB-fold domain / DNA polymerase delta subunit 2, C-terminal domain / DNA polymerase delta subunit OB-fold domain / DNA polymerase delta/II small subunit family / 50s Ribosomal Protein L17; Chain: A, / DNA polymerase alpha/delta/epsilon, subunit B / DNA polymerase alpha/epsilon subunit B / Purple Acid Phosphatase; chain A, domain 2 / 4-Layer Sandwich / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Alpha-Beta Complex / Beta Barrel / Mainly Beta / Alpha Beta Similarity search - Domain/homology
#1: Journal: Acta Crystallogr.,Sect.F / Year: 2008 Title: Crystallization and preliminary crystallographic analysis of the complex of the second and third regulatory subunits of human Pol delta. Authors: Baranovskiy, A.G. / Babayeva, N.D. / Pavlov, Y.I. / Tahirov, T.H.
A: DNA polymerase subunit delta-2 B: DNA polymerase subunit delta-3 C: DNA polymerase subunit delta-2 D: DNA polymerase subunit delta-3 E: DNA polymerase subunit delta-2 F: DNA polymerase subunit delta-3 G: DNA polymerase subunit delta-2 H: DNA polymerase subunit delta-3
DNApolymerasesubunitdelta-2 / DNA polymerase subunit delta p50
Mass: 52224.102 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P49005, DNA-directed DNA polymerase
#2: Protein
DNApolymerasesubunitdelta-3 / DNA polymerase subunit delta p66
Mass: 16233.576 Da / Num. of mol.: 4 / Fragment: residues 1-144 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: Q15054
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