- PDB-3cuq: Integrated structural and functional model of the human ESCRT-II ... -
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Basic information
Entry
Database: PDB / ID: 3cuq
Title
Integrated structural and functional model of the human ESCRT-II complex
Components
Vacuolar protein-sorting-associated protein 25
Vacuolar protein-sorting-associated protein 36
Vacuolar-sorting protein SNF8
Keywords
PROTEIN TRANSPORT / ESCRT / Sorting / MBV / vps / Nucleus / Transcription / Transcription regulation / Transport / Endosome / Lipid-binding
Function / homology
Function and homology information
ESCRT II complex / negative regulation of epidermal growth factor-activated receptor activity / protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / regulation of protein complex stability / multivesicular body sorting pathway / membrane fission / early endosome to late endosome transport / positive regulation of exosomal secretion / multivesicular body assembly / channel regulator activity ...ESCRT II complex / negative regulation of epidermal growth factor-activated receptor activity / protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / regulation of protein complex stability / multivesicular body sorting pathway / membrane fission / early endosome to late endosome transport / positive regulation of exosomal secretion / multivesicular body assembly / channel regulator activity / phosphatidylinositol-3-phosphate binding / endocytic recycling / regulation of protein catabolic process / localization / Endosomal Sorting Complex Required For Transport (ESCRT) / HCMV Late Events / ubiquitin binding / macroautophagy / recycling endosome / positive regulation of protein catabolic process / late endosome membrane / transcription regulator complex / lysosome / endosome membrane / endosome / intracellular membrane-bounded organelle / lipid binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / structural molecule activity / perinuclear region of cytoplasm / protein homodimerization activity / extracellular exosome / nucleoplasm / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function
Helix Hairpins - #260 / ESCRT-2 complex, Snf8 / "Winged helix" DNA-binding domain. Chain C. Domain 1 / ESCRT-II complex, Vps25 subunit, N-terminal winged helix / ESCRT-II complex, Vps25 subunit / ESCRT-II complex subunit / Vacuolar protein sorting protein 36, GLUE domain / Vacuolar protein sorting protein 36 / Snf8/Vps36 family / EAP30/Vps36 family ...Helix Hairpins - #260 / ESCRT-2 complex, Snf8 / "Winged helix" DNA-binding domain. Chain C. Domain 1 / ESCRT-II complex, Vps25 subunit, N-terminal winged helix / ESCRT-II complex, Vps25 subunit / ESCRT-II complex subunit / Vacuolar protein sorting protein 36, GLUE domain / Vacuolar protein sorting protein 36 / Snf8/Vps36 family / EAP30/Vps36 family / Vacuolar protein sorting protein 36 Vps36 / GLUE domain profile. / Helix Hairpins / Helix non-globular / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Special / PH-like domain superfamily / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Vacuolar protein-sorting-associated protein 36 / Vacuolar-sorting protein SNF8 / Vacuolar protein-sorting-associated protein 25 Similarity search - Component
Biological species
Homo sapiens (human)
Method
X-RAY DIFFRACTION / SYNCHROTRON / MIR / Resolution: 2.61 Å
A: Vacuolar-sorting protein SNF8 B: Vacuolar protein-sorting-associated protein 36 C: Vacuolar protein-sorting-associated protein 25 D: Vacuolar protein-sorting-associated protein 25
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