登録情報 データベース : PDB / ID : 3cjo 構造の表示 ダウンロードとリンクタイトル Crystal structure of KSP in complex with inhibitor 30 要素Kinesin-like protein KIF11 詳細 キーワード MOTOR PROTEIN / KSP / KSP-inhibitor complex / ATP-binding / Cell cycle / Cell division / Coiled coil / Microtubule / Mitosis / Nucleotide-binding / Phosphoprotein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
spindle elongation / regulation of mitotic centrosome separation / Kinesins / plus-end-directed microtubule motor activity / mitotic centrosome separation / COPI-dependent Golgi-to-ER retrograde traffic / microtubule motor activity / kinesin complex / spindle organization / microtubule-based movement ... spindle elongation / regulation of mitotic centrosome separation / Kinesins / plus-end-directed microtubule motor activity / mitotic centrosome separation / COPI-dependent Golgi-to-ER retrograde traffic / microtubule motor activity / kinesin complex / spindle organization / microtubule-based movement / mitotic spindle assembly / MHC class II antigen presentation / mitotic spindle organization / spindle microtubule / mitotic spindle / spindle pole / spindle / mitotic cell cycle / microtubule binding / microtubule / cell division / protein kinase binding / protein-containing complex / ATP binding / membrane / nucleus / cytosol 類似検索 - 分子機能 Kinesin-associated microtubule-binding domain / Kinesin-associated microtubule-binding / : / : / Kinesin motor domain / Kinesin / Kinesin motor domain signature. / Kinesin motor domain, conserved site / Kinesin motor domain / Kinesin motor domain profile. ... Kinesin-associated microtubule-binding domain / Kinesin-associated microtubule-binding / : / : / Kinesin motor domain / Kinesin / Kinesin motor domain signature. / Kinesin motor domain, conserved site / Kinesin motor domain / Kinesin motor domain profile. / Kinesin motor, catalytic domain. ATPase. / Kinesin motor domain / Kinesin motor domain superfamily / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / Chem-K30 / Kinesin-like protein KIF11 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / フーリエ合成 / 解像度 : 2.28 Å 詳細データ登録者 Yan, Y. 引用ジャーナル : J.Med.Chem. / 年 : 2008タイトル: Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H- ... タイトル : Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.著者: Cox, C.D. / Coleman, P.J. / Breslin, M.J. / Whitman, D.B. / Garbaccio, R.M. / Fraley, M.E. / Buser, C.A. / Walsh, E.S. / Hamilton, K. / Schaber, M.D. / Lobell, R.B. / Tao, W. / Davide, J.P. / ... 著者 : Cox, C.D. / Coleman, P.J. / Breslin, M.J. / Whitman, D.B. / Garbaccio, R.M. / Fraley, M.E. / Buser, C.A. / Walsh, E.S. / Hamilton, K. / Schaber, M.D. / Lobell, R.B. / Tao, W. / Davide, J.P. / Diehl, R.E. / Abrams, M.T. / South, V.J. / Huber, H.E. / Torrent, M. / Prueksaritanont, T. / Li, C. / Slaughter, D.E. / Mahan, E. / Fernandez-Metzler, C. / Yan, Y. / Kuo, L.C. / Kohl, N.E. / Hartman, G.D. 履歴 登録 2008年3月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年7月1日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年8月30日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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