Entry Database : PDB / ID : 3c7k Structure visualization Downloads & linksTitle Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation ComponentsGuanine nucleotide-binding protein G(o) subunit alpha Regulator of G-protein signaling 16 DetailsKeywords SIGNALING PROTEIN / RGS / Galpha / AlF4 heterotrimeric G-protein GAP / GTP-binding / Lipoprotein / Myristate / Nucleotide-binding / Palmitate / Transducer / Phosphoprotein / Signal transduction inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
cellular process / PLC beta mediated events / G alpha (z) signalling events / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / G-protein activation / Ca2+ pathway / G alpha (q) signalling events / : / response to xenobiotic stimulus => GO:0009410 / G alpha (i) signalling events ... cellular process / PLC beta mediated events / G alpha (z) signalling events / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / G-protein activation / Ca2+ pathway / G alpha (q) signalling events / : / response to xenobiotic stimulus => GO:0009410 / G alpha (i) signalling events / response to morphine / GTPase activating protein binding / G protein-coupled dopamine receptor signaling pathway / regulation of heart contraction / odontogenesis of dentin-containing tooth / negative regulation of calcium ion transport / mu-type opioid receptor binding / corticotropin-releasing hormone receptor 1 binding / G protein-coupled serotonin receptor binding / negative regulation of signal transduction / forebrain development / : / GTPase activator activity / positive regulation of GTPase activity / response to cytokine / locomotory behavior / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / response to hydrogen peroxide / neuron projection development / heterotrimeric G-protein complex / myelin sheath / cell body / neuron projection / G protein-coupled receptor signaling pathway / signaling receptor binding / GTPase activity / dendrite / protein-containing complex binding / GTP binding / protein-containing complex / membrane / metal ion binding / plasma membrane / cytoplasm Similarity search - Function Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain ... Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(o) subunit alpha / Regulator of G-protein signaling 16 Similarity search - ComponentBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.9 Å DetailsAuthors Slep, K.C. / Kercher, M.A. / Wieland, T. / Chen, C. / Simon, M.I. / Sigler, P.B. CitationJournal : Proc.Natl.Acad.Sci.Usa / Year : 2008Title : Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation.Authors : Slep, K.C. / Kercher, M.A. / Wieland, T. / Chen, C.K. / Simon, M.I. / Sigler, P.B. History Deposition Feb 7, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 6, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Oct 25, 2017 Group : Refinement description / Category : softwareRevision 1.3 Aug 30, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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