登録情報 | データベース: PDB / ID: 3c7k |
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タイトル | Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation |
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要素 | - Guanine nucleotide-binding protein G(o) subunit alpha
- Regulator of G-protein signaling 16
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キーワード | SIGNALING PROTEIN / RGS / Galpha / AlF4 heterotrimeric G-protein GAP / GTP-binding / Lipoprotein (リポタンパク質) / Myristate (ミリスチン酸) / Nucleotide-binding / Palmitate (パルミチン酸) / Transducer (トランスデューサー) / Phosphoprotein / Signal transduction inhibitor |
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機能・相同性 | 機能・相同性情報
細胞 / PLC beta mediated events / G alpha (z) signalling events / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / G-protein activation / Ca2+ pathway / G alpha (q) signalling events / : / response to xenobiotic stimulus => GO:0009410 / G alpha (i) signalling events ...細胞 / PLC beta mediated events / G alpha (z) signalling events / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / G-protein activation / Ca2+ pathway / G alpha (q) signalling events / : / response to xenobiotic stimulus => GO:0009410 / G alpha (i) signalling events / mu-type opioid receptor binding / corticotropin-releasing hormone receptor 1 binding / response to morphine / GTPase activating protein binding / regulation of heart contraction / dopamine receptor signaling pathway / odontogenesis of dentin-containing tooth / negative regulation of calcium ion transport / G protein-coupled serotonin receptor binding / negative regulation of signal transduction / forebrain development / response to organonitrogen compound / GTPase activator activity / locomotory behavior / G protein-coupled receptor binding / response to cytokine / G-protein beta/gamma-subunit complex binding / response to hydrogen peroxide / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / positive regulation of GTPase activity / neuron projection development / heterotrimeric G-protein complex / 髄鞘 / cell body / neuron projection / G protein-coupled receptor signaling pathway / signaling receptor binding / GTPase activity / 樹状突起 / protein-containing complex binding / GTP binding / protein-containing complex / 生体膜 / metal ion binding / 細胞膜 / 細胞質類似検索 - 分子機能 Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain ...Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(o) subunit alpha / Regulator of G-protein signaling 16類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Slep, K.C. / Kercher, M.A. / Wieland, T. / Chen, C. / Simon, M.I. / Sigler, P.B. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.Usa / 年: 2008 タイトル: Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. 著者: Slep, K.C. / Kercher, M.A. / Wieland, T. / Chen, C.K. / Simon, M.I. / Sigler, P.B. |
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履歴 | 登録 | 2008年2月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年5月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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