- PDB-3bs5: Crystal Structure of hCNK2-SAM/dHYP-SAM Complex -
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基本情報
登録情報
データベース: PDB / ID: 3bs5
タイトル
Crystal Structure of hCNK2-SAM/dHYP-SAM Complex
要素
Connector enhancer of kinase suppressor of ras 2
Protein aveugle
キーワード
Signaling PROTEIN/membrane protein / Sterile alpha motif / SAM domain / SAM domain dimer / SAM domain complex / Cytoplasm / Membrane / Sensory transduction / Vision / Alternative splicing / Coiled coil / Phosphoprotein / Polymorphism / Signaling PROTEIN-membrane protein COMPLEX
機能・相同性
機能・相同性情報
Phosphorylation of CI / compound eye cone cell differentiation / Phosphorylation of SMO / compound eye photoreceptor cell differentiation / Phosphorylation of PER and TIM / eye photoreceptor cell differentiation / extrinsic component of postsynaptic density membrane / postsynapse organization / positive regulation of Ras protein signal transduction / regulation of signal transduction ...Phosphorylation of CI / compound eye cone cell differentiation / Phosphorylation of SMO / compound eye photoreceptor cell differentiation / Phosphorylation of PER and TIM / eye photoreceptor cell differentiation / extrinsic component of postsynaptic density membrane / postsynapse organization / positive regulation of Ras protein signal transduction / regulation of signal transduction / cell surface receptor protein tyrosine kinase signaling pathway / visual perception / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / epidermal growth factor receptor signaling pathway / cytoplasmic side of plasma membrane / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / scaffold protein binding / positive regulation of ERK1 and ERK2 cascade / intracellular signal transduction / neuronal cell body / glutamatergic synapse / protein kinase binding / extracellular exosome / identical protein binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Connector enhancer of kinase suppressor of ras 2/3 domain / Connector enhancer of kinase suppressor of ras 2/3 domain / Aveugle-like, SAM domain / : / CRIC domain / Connector enhancer of kinase suppressor of ras / CRIC domain profile. / Transcription Factor, Ets-1 / SAM domain (Sterile alpha motif) / SAM domain (Sterile alpha motif) ...Connector enhancer of kinase suppressor of ras 2/3 domain / Connector enhancer of kinase suppressor of ras 2/3 domain / Aveugle-like, SAM domain / : / CRIC domain / Connector enhancer of kinase suppressor of ras / CRIC domain profile. / Transcription Factor, Ets-1 / SAM domain (Sterile alpha motif) / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / PH domain / Sterile alpha motif/pointed domain superfamily / PH domain profile. / PDZ domain / Pleckstrin homology domain. / Pleckstrin homology domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / DNA polymerase; domain 1 / PH-like domain superfamily / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性
Protein aveugle / Connector enhancer of kinase suppressor of ras 2 類似検索 - 構成要素
生物種
Drosophila melanogaster (キイロショウジョウバエ) Homo sapiens (ヒト)
構造決定の手法: 単波長異常分散 / 解像度: 2→19.87 Å / Cor.coef. Fo:Fc: 0.941 / Cor.coef. Fo:Fc free: 0.925 / SU B: 3.228 / SU ML: 0.093 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.167 / ESU R Free: 0.149 立体化学のターゲット値: MAXIMUM LIKELIHOOD WITH PHASES 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.24
786
4.9 %
RANDOM
Rwork
0.212
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all
0.214
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-
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obs
0.214
15619
99.67 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK