Entry | Database: PDB / ID: 3a6p |
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Title | Crystal structure of Exportin-5:RanGTP:pre-miRNA complex |
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Components | - (pre-microRNA) x 2
- 13-mer peptide
- Exportin-5
- GTP-binding nuclear protein Ran
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Keywords | PROTEIN TRANSPORT/NUCLEAR PROTEIN/RNA / EXPORTIN-5 / PRE-MICRORNA / RANGTP / NUCLEAREXPORT / IMPORTIN-BETA FAMILY / Nucleus / Phosphoprotein / Protein transport / RNA-binding / RNA-mediated gene silencing / Transport / tRNA-binding / Cell cycle / Cell division / GTP-binding / Isopeptide bond / Mitosis / Nucleotide-binding / PROTEIN TRANSPORT-NUCLEAR PROTEIN-RNA COMPLEX |
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Function / homology | Function and homology information
RISC complex binding / pre-miRNA binding / RNA nuclear export complex / pre-miRNA export from nucleus / nuclear export signal receptor activity / miRNA metabolic process / snRNA import into nucleus / GTP metabolic process / RISC complex / RNA export from nucleus ...RISC complex binding / pre-miRNA binding / RNA nuclear export complex / pre-miRNA export from nucleus / nuclear export signal receptor activity / miRNA metabolic process / snRNA import into nucleus / GTP metabolic process / RISC complex / RNA export from nucleus / MicroRNA (miRNA) biogenesis / mitotic sister chromatid segregation / ribosomal subunit export from nucleus / protein export from nucleus / positive regulation of protein export from nucleus / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / small GTPase binding / protein import into nucleus / melanosome / nuclear envelope / tRNA binding / cell division / GTPase activity / mRNA binding / GTP binding / magnesium ion binding / protein-containing complex / RNA binding / nucleoplasm / nucleus / cytoplasm / cytosolSimilarity search - Function Exportin-5, C-terminal domain / Exportin-5 family / Exportin-1/5 / Exportin-1/Importin-beta-like / Exportin 1-like protein / small GTPase Ran family profile. / Ran GTPase / Importin-beta N-terminal domain / Importin-beta N-terminal domain / Importin-beta, N-terminal domain ...Exportin-5, C-terminal domain / Exportin-5 family / Exportin-1/5 / Exportin-1/Importin-beta-like / Exportin 1-like protein / small GTPase Ran family profile. / Ran GTPase / Importin-beta N-terminal domain / Importin-beta N-terminal domain / Importin-beta, N-terminal domain / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Armadillo-like helical / Alpha Horseshoe / Small GTP-binding protein domain / Armadillo-type fold / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human)
![](img/tx_mammal.gif) Canis lupus familiaris (dog) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution: 2.92 Å |
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Authors | Okada, C. / Yamashita, E. / Lee, S.J. / Shibata, S. / Katahira, J. / Nakagawa, A. / Yoneda, Y. / Tsukihara, T. |
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Citation | Journal: Science / Year: 2009 Title: A high-resolution structure of the pre-microRNA nuclear export machinery Authors: Okada, C. / Yamashita, E. / Lee, S.J. / Shibata, S. / Katahira, J. / Nakagawa, A. / Yoneda, Y. / Tsukihara, T. |
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History | Deposition | Sep 7, 2009 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Dec 8, 2009 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.2 | Apr 25, 2012 | Group: Database references |
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