- PDB-2yuu: Solution structure of the first Phorbol esters/diacylglycerol bin... -
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Basic information
Entry
Database: PDB / ID: 2yuu
Title
Solution structure of the first Phorbol esters/diacylglycerol binding domain of human Protein kinase C, delta
Components
Protein kinase C delta type
Keywords
TRANSFERASE / Metal Binding Protein / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / endolysosome / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction ...positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / endolysosome / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction / negative regulation of filopodium assembly / DAG and IP3 signaling / protein kinase C / cellular response to hydroperoxide / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / Effects of PIP2 hydrolysis / negative regulation of actin filament polymerization / negative regulation of platelet aggregation / positive regulation of endodeoxyribonuclease activity / neutrophil activation / regulation of signaling receptor activity / cellular response to angiotensin / Calmodulin induced events / intrinsic apoptotic signaling pathway in response to oxidative stress / Fc-gamma receptor signaling pathway involved in phagocytosis / activation of protein kinase activity / B cell proliferation / Apoptotic cleavage of cellular proteins / insulin receptor substrate binding / RHO GTPases Activate NADPH Oxidases / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / positive regulation of protein dephosphorylation / enzyme activator activity / regulation of mRNA stability / negative regulation of insulin receptor signaling pathway / SHC1 events in ERBB2 signaling / post-translational protein modification / cell chemotaxis / positive regulation of superoxide anion generation / VEGFR2 mediated cell proliferation / negative regulation of MAP kinase activity / negative regulation of protein binding / regulation of actin cytoskeleton organization / positive regulation of apoptotic signaling pathway / peptidyl-threonine phosphorylation / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / CLEC7A (Dectin-1) signaling / nuclear matrix / negative regulation of inflammatory response / cellular response to hydrogen peroxide / positive regulation of protein import into nucleus / G alpha (z) signalling events / cellular response to UV / Interferon gamma signaling / KEAP1-NFE2L2 pathway / azurophil granule lumen / cellular senescence / cell-cell junction / peptidyl-serine phosphorylation / protein stabilization / protein kinase activity / intracellular signal transduction / defense response to bacterium / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / DNA damage response / Neutrophil degranulation / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / signal transduction / mitochondrion / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) ...Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Conformer selection criteria: structures with the least restraint violations,target function Conformers calculated total number: 100 / Conformers submitted total number: 20
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