- PDB-2yuu: Solution structure of the first Phorbol esters/diacylglycerol bin... -
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基本情報
登録情報
データベース: PDB / ID: 2yuu
タイトル
Solution structure of the first Phorbol esters/diacylglycerol binding domain of human Protein kinase C, delta
要素
Protein kinase C delta type
キーワード
TRANSFERASE (転移酵素) / Metal Binding Protein / Structural Genomics (構造ゲノミクス) / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
機能・相同性
機能・相同性情報
positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / ファゴリソソーム / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction ...positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / ファゴリソソーム / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction / negative regulation of filopodium assembly / DAG and IP3 signaling / protein kinase C / cellular response to hydroperoxide / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / Effects of PIP2 hydrolysis / negative regulation of actin filament polymerization / 好中球 / positive regulation of endodeoxyribonuclease activity / negative regulation of platelet aggregation / regulation of signaling receptor activity / cellular response to angiotensin / Calmodulin induced events / intrinsic apoptotic signaling pathway in response to oxidative stress / Fc-gamma receptor signaling pathway involved in phagocytosis / B cell proliferation / Apoptotic cleavage of cellular proteins / activation of protein kinase activity / immunoglobulin mediated immune response / enzyme activator activity / insulin receptor substrate binding / RHO GTPases Activate NADPH Oxidases / Role of phospholipids in phagocytosis / positive regulation of apoptotic signaling pathway / positive regulation of protein dephosphorylation / negative regulation of insulin receptor signaling pathway / regulation of mRNA stability / SHC1 events in ERBB2 signaling / cell chemotaxis / post-translational protein modification / positive regulation of superoxide anion generation / negative regulation of protein binding / negative regulation of MAP kinase activity / VEGFR2 mediated cell proliferation / regulation of actin cytoskeleton organization / peptidyl-threonine phosphorylation / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cellular response to hydrogen peroxide / CLEC7A (Dectin-1) signaling / G alpha (z) signalling events / nuclear matrix / negative regulation of inflammatory response / positive regulation of protein import into nucleus / cellular response to UV / azurophil granule lumen / KEAP1-NFE2L2 pathway / Interferon gamma signaling / 細胞老化 / cell-cell junction / peptidyl-serine phosphorylation / protein stabilization / protein kinase activity / intracellular signal transduction / defense response to bacterium / 細胞周期 / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / DNA damage response / Neutrophil degranulation / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / 小胞体 / シグナル伝達 / ミトコンドリア / extracellular exosome / extracellular region / 核質 / ATP binding / metal ion binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能
Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) ...Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2ドメイン / C2 domain profile. / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性