登録情報 | データベース: PDB / ID: 2y3a |
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タイトル | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 |
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要素 | - PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA
- PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
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キーワード | TRANSFERASE / PHOSPHOINOSITIDE 3-KINASE / RTK |
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機能・相同性 | 機能・相同性情報
RHOJ GTPase cycle / IRS-mediated signalling / Signaling by ALK / Signaling by LTK / Tie2 Signaling / RND3 GTPase cycle / PI3K/AKT activation / PI3K Cascade / Role of LAT2/NTAL/LAB on calcium mobilization / RHOF GTPase cycle ...RHOJ GTPase cycle / IRS-mediated signalling / Signaling by ALK / Signaling by LTK / Tie2 Signaling / RND3 GTPase cycle / PI3K/AKT activation / PI3K Cascade / Role of LAT2/NTAL/LAB on calcium mobilization / RHOF GTPase cycle / RHOU GTPase cycle / RAC3 GTPase cycle / RAC2 GTPase cycle / Downstream signal transduction / CDC42 GTPase cycle / GPVI-mediated activation cascade / Interleukin-7 signaling / RHOD GTPase cycle / negative regulation of sprouting angiogenesis / Signaling by SCF-KIT / RND2 GTPase cycle / RND1 GTPase cycle / Role of phospholipids in phagocytosis / negative regulation of vascular endothelial growth factor signaling pathway / Co-stimulation by ICOS / RAC1 GTPase cycle / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / CD28 dependent PI3K/Akt signaling / RHOB GTPase cycle / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / G alpha (q) signalling events / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway / positive regulation of neutrophil apoptotic process / PIP3 activates AKT signaling / Downstream TCR signaling / RHOA GTPase cycle / Regulation of signaling by CBL / regulation of cell-matrix adhesion / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling / regulation of actin filament polymerization / phosphatidylinositol 3-kinase regulatory subunit binding / embryonic cleavage / VEGFA-VEGFR2 Pathway / regulation of stress fiber assembly / sphingosine-1-phosphate receptor signaling pathway / phosphatidylinositol 3-kinase complex, class IA / angiogenesis involved in wound healing / endothelial cell proliferation / DAP12 signaling / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / phosphatidylinositol-4,5-bisphosphate 3-kinase / 1-phosphatidylinositol-3-kinase activity / natural killer cell mediated cytotoxicity / homophilic cell adhesion via plasma membrane adhesion molecules / intracellular glucose homeostasis / phosphatidylinositol phosphate biosynthetic process / positive regulation of Rac protein signal transduction / insulin receptor substrate binding / regulation of protein localization to plasma membrane / negative regulation of MAPK cascade / phosphotyrosine residue binding / positive regulation of endothelial cell migration / positive regulation of cell adhesion / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to endoplasmic reticulum stress / response to ischemia / phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor tyrosine kinase binding / platelet activation / autophagy / positive regulation of protein import into nucleus / intracellular calcium ion homeostasis / cellular response to insulin stimulus / endocytosis / positive regulation of nitric oxide biosynthetic process / insulin receptor signaling pathway / protein transport / midbody / protein phosphatase binding / non-specific serine/threonine protein kinase / regulation of autophagy / protein heterodimerization activity / protein serine kinase activity / focal adhesion / positive regulation of gene expression / nucleolus / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / nucleus / cytosol類似検索 - 分子機能 PI3Kbeta, catalytic domain / Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / Ubiquitin-like (UB roll) - #770 / Helix Hairpins - #1490 / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 ...PI3Kbeta, catalytic domain / Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / Ubiquitin-like (UB roll) - #770 / Helix Hairpins - #1490 / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 / Phosphatidylinositol 3-/4-kinase, catalytic domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Phosphatidylinositol 3-kinase, accessory domain (PIK) / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Rho GTPase activation protein / C2 phosphatidylinositol 3-kinase-type domain / Phosphoinositide 3-kinase C2 / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, region postulated to contain C2 domain / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / C2 domain / SH2 domain / SHC Adaptor Protein / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ubiquitin-like (UB roll) / Helix Hairpins / Alpha Horseshoe / Armadillo-type fold / Ubiquitin-like domain superfamily / Roll / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-GD9 / Phosphatidylinositol 3-kinase regulatory subunit beta / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform類似検索 - 構成要素 |
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生物種 |  MUS MUSCULUS (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å |
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データ登録者 | Zhang, X. / Vadas, O. / Perisic, O. / Williams, R.L. |
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引用 | ジャーナル: Mol.Cell / 年: 2011 タイトル: Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. 著者: Zhang, X. / Vadas, O. / Perisic, O. / Anderson, K.E. / Clark, J. / Hawkins, P.T. / Stephens, L.R. / Williams, R.L. |
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履歴 | 登録 | 2010年12月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2011年3月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年5月8日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2019年4月3日 | Group: Data collection / Other / Source and taxonomy カテゴリ: entity_src_gen / pdbx_database_proc / pdbx_database_status Item: _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval |
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改定 1.4 | 2023年12月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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