GTPase complex / oncogene-induced cell senescence / positive regulation of ruffle assembly / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / negative regulation of GTPase activity / T-helper 1 type immune response / positive regulation of wound healing / positive regulation of miRNA metabolic process / defense response to protozoan / Signaling by RAS GAP mutants ...GTPase complex / oncogene-induced cell senescence / positive regulation of ruffle assembly / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / negative regulation of GTPase activity / T-helper 1 type immune response / positive regulation of wound healing / positive regulation of miRNA metabolic process / defense response to protozoan / Signaling by RAS GAP mutants / Signaling by RAS GTPase mutants / Activation of RAS in B cells / RAS signaling downstream of NF1 loss-of-function variants / SOS-mediated signalling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / SHC1 events in ERBB4 signaling / positive regulation of protein targeting to membrane / Signalling to RAS / SHC-related events triggered by IGF1R / Activated NTRK2 signals through FRS2 and FRS3 / Estrogen-stimulated signaling through PRKCZ / adipose tissue development / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / : / Schwann cell development / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / SHC-mediated cascade:FGFR2 / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / SHC-mediated cascade:FGFR4 / Signaling by FGFR4 in disease / SHC-mediated cascade:FGFR1 / Erythropoietin activates RAS / protein-membrane adaptor activity / FRS-mediated FGFR3 signaling / Signaling by FLT3 ITD and TKD mutants / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / p38MAPK events / Tie2 Signaling / FRS-mediated FGFR1 signaling / Signaling by FGFR2 in disease / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / EPHB-mediated forward signaling / EGFR Transactivation by Gastrin / Signaling by FLT3 fusion proteins / FLT3 Signaling / myelination / Ras activation upon Ca2+ influx through NMDA receptor / Signaling by FGFR1 in disease / GRB2 events in ERBB2 signaling / NCAM signaling for neurite out-growth / CD209 (DC-SIGN) signaling / SHC1 events in ERBB2 signaling / Downstream signal transduction / Constitutive Signaling by Overexpressed ERBB2 / Insulin receptor signalling cascade / intrinsic apoptotic signaling pathway / small monomeric GTPase / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / G protein activity / positive regulation of GTPase activity / VEGFR2 mediated cell proliferation / positive regulation of epithelial cell proliferation / regulation of actin cytoskeleton organization / FCERI mediated MAPK activation / animal organ morphogenesis / positive regulation of JNK cascade / Signaling by ERBB2 TMD/JMD mutants / RAF activation / regulation of long-term neuronal synaptic plasticity / positive regulation of MAP kinase activity / Signaling by high-kinase activity BRAF mutants / Constitutive Signaling by EGFRvIII / MAP2K and MAPK activation / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / Signaling by SCF-KIT / cellular response to gamma radiation / Regulation of RAS by GAPs / endocytosis / Negative regulation of MAPK pathway / RAS processing / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / GDP binding / chemotaxis / MAPK cascade / cellular senescence / Signaling by BRAF and RAF1 fusions / positive regulation of type II interferon production / positive regulation of fibroblast proliferation / insulin receptor signaling pathway / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Similarity search - Function
Small GTPase, Ras-type / small GTPase Ras family profile. / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase ...Small GTPase, Ras-type / small GTPase Ras family profile. / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology
Resolution: 1.7→28.285 Å / SU ML: 0.05 / σ(F): 1.99 / Phase error: 29.13 / Stereochemistry target values: TWIN_LSQ_F Details: HRAS ILE163PHE PATIENT MUTANT LACK BOTH LOOPS THAT ARE INVOLVED IN THE (DISORDERED RESIDUE 30-38 AND 58-69) SWITCH I AND II.
Rfactor
Num. reflection
% reflection
Rfree
0.2272
1054
5 %
Rwork
0.1899
-
-
obs
0.1907
21075
99.77 %
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.55 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 96.88 Å2 / ksol: 0.413 e/Å3
Displacement parameters
Baniso -1
Baniso -2
Baniso -3
1-
-3.1443 Å2
-0 Å2
0 Å2
2-
-
-3.1443 Å2
-0 Å2
3-
-
-
6.2886 Å2
Refinement step
Cycle: LAST / Resolution: 1.7→28.285 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
1085
0
28
116
1229
Refine LS restraints
Refine-ID
Type
Dev ideal
Number
X-RAY DIFFRACTION
f_bond_d
0.006
1128
X-RAY DIFFRACTION
f_angle_d
1.089
1529
X-RAY DIFFRACTION
f_dihedral_angle_d
19.677
405
X-RAY DIFFRACTION
f_chiral_restr
0.066
177
X-RAY DIFFRACTION
f_plane_restr
0.003
193
LS refinement shell
Resolution (Å)
Rfactor Rfree
Num. reflection Rfree
Rfactor Rwork
Num. reflection Rwork
Refine-ID
% reflection obs (%)
1.7002-1.7898
0.3116
151
0.2787
2856
X-RAY DIFFRACTION
95
1.7898-1.9019
0.3113
148
0.2859
2817
X-RAY DIFFRACTION
95
1.9019-2.0487
0.263
151
0.2437
2861
X-RAY DIFFRACTION
95
2.0487-2.2548
0.2579
149
0.2384
2846
X-RAY DIFFRACTION
95
2.2548-2.5809
0.2597
151
0.2281
2869
X-RAY DIFFRACTION
95
2.5809-3.2508
0.24
152
0.1905
2871
X-RAY DIFFRACTION
95
3.2508-28.1655
0.1779
152
0.1328
2888
X-RAY DIFFRACTION
94
Refinement TLS params.
Method: refined / Origin x: 16.9216 Å / Origin y: -28.123 Å / Origin z: -0.8268 Å
11
12
13
21
22
23
31
32
33
T
0.1095 Å2
0.0011 Å2
-0.0115 Å2
-
0.1362 Å2
0.0064 Å2
-
-
0.1837 Å2
L
0.1671 °2
0.0522 °2
0.0949 °2
-
0.9188 °2
-0.0048 °2
-
-
0.2546 °2
S
-0.0464 Å °
-0.0769 Å °
0.09 Å °
-0.0268 Å °
0.0401 Å °
-0.1261 Å °
0.0032 Å °
-0.017 Å °
0.0111 Å °
Refinement TLS group
Selection details: CHAIN A
+
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