Entry Database : PDB / ID : 2wok Structure visualization Downloads & linksTitle Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin ComponentsCLAVULANIC ACID BIOSYNTHESIS OLIGOPEPTIDE BINDING PROTEIN 2 Kininogen-1 DetailsKeywords PEPTIDE BINDING PROTEIN/PEPTIDE / PEPTIDE BINDING PROTEIN-PEPTIDE COMPLEX / SOLUTE-BINDING PROTEIN / CLAVULANIC ACID BIOSYNTHESIS / OLIGOPEPTIDE BINDING PROTEIN / OLIGOPEPTIDE / BRADYKININFunction / homology Function and homology informationFunction Domain/homology Component
clavulanic acid biosynthetic process / peptide transport / negative regulation of cell adhesion / negative regulation of blood coagulation / peptide transmembrane transporter activity / cysteine-type endopeptidase inhibitor activity / Intrinsic Pathway of Fibrin Clot Formation / ATP-binding cassette (ABC) transporter complex / Peptide ligand-binding receptors / platelet alpha granule lumen ... clavulanic acid biosynthetic process / peptide transport / negative regulation of cell adhesion / negative regulation of blood coagulation / peptide transmembrane transporter activity / cysteine-type endopeptidase inhibitor activity / Intrinsic Pathway of Fibrin Clot Formation / ATP-binding cassette (ABC) transporter complex / Peptide ligand-binding receptors / platelet alpha granule lumen / negative regulation of proteolysis / Post-translational protein phosphorylation / hormone activity / vasodilation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / blood coagulation / Platelet degranulation / heparin binding / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / outer membrane-bounded periplasmic space / G alpha (q) signalling events / collagen-containing extracellular matrix / blood microparticle / inflammatory response / positive regulation of apoptotic process / endoplasmic reticulum lumen / signaling receptor binding / extracellular space / zinc ion binding / extracellular exosome / extracellular region / plasma membrane Similarity search - Function HMW kininogen / Kininogen-type cystatin domain / Kininogen-type cystatin domain profile. / Proteinase inhibitor I25, cystatin, conserved site / Cysteine proteases inhibitors signature. / Cystatin domain / Cystatin-like domain / Cystatin domain / Dipeptide-binding Protein; domain 3 / Dipeptide-binding Protein; Domain 3 ... HMW kininogen / Kininogen-type cystatin domain / Kininogen-type cystatin domain profile. / Proteinase inhibitor I25, cystatin, conserved site / Cysteine proteases inhibitors signature. / Cystatin domain / Cystatin-like domain / Cystatin domain / Dipeptide-binding Protein; domain 3 / Dipeptide-binding Protein; Domain 3 / Cystatin superfamily / Peptide/nickel binding protein, MppA-type / Solute-binding protein family 5 domain / Solute-binding protein family 5 / Bacterial extracellular solute-binding proteins, family 5 Middle / Periplasmic binding protein-like II / D-Maltodextrin-Binding Protein; domain 2 / Roll / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Streptomyces clavuligerus (bacteria)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.7 Å DetailsAuthors Mackenzie, A.K. / Valegard, K. / Iqbal, A. / Caines, M.E.C. / Kershaw, N.J. / Jensen, S.E. / Schofield, C.J. / Andersson, I. CitationJournal : J. Mol. Biol. / Year : 2010Title : Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.Authors : Mackenzie, A.K. / Valegard, K. / Iqbal, A. / Caines, M.E. / Kershaw, N.J. / Jensen, S.E. / Schofield, C.J. / Andersson, I. History Deposition Jul 26, 2009 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 8, 2009 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 12, 2018 Group : Data collection / Database references ... Data collection / Database references / Source and taxonomy / Structure summary Category : audit_author / citation ... audit_author / citation / citation_author / entity / entity_name_com / entity_src_gen / pdbx_entity_src_syn / struct_ref Item : _audit_author.name / _citation.journal_abbrev ... _audit_author.name / _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name / _entity.pdbx_description / _entity.src_method / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_seq_one_letter_code Revision 1.4 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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