登録情報 | データベース: PDB / ID: 2wnt |
---|
タイトル | Crystal Structure of the Human Ribosomal protein S6 kinase |
---|
要素 | RIBOSOMAL PROTEIN S6 KINASE |
---|
キーワード | TRANSFERASE / ATP-BINDING / POLYMORPHISM / METAL-BINDING / HUMAN / KINASE / RIBOSOMAL / MAGNESIUM / SERINE/THREONINE-PROTEIN KINASE / PHOSPHOPROTEIN / NUCLEOTIDE-BINDING |
---|
機能・相同性 | 機能・相同性情報
regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / negative regulation of TOR signaling / ERK/MAPK targets ...regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / negative regulation of TOR signaling / ERK/MAPK targets / Recycling pathway of L1 / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protein serine/threonine/tyrosine kinase activity / positive regulation of cell differentiation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / Senescence-Associated Secretory Phenotype (SASP) / positive regulation of cell growth / chemical synaptic transmission / non-specific serine/threonine protein kinase / intracellular signal transduction / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / synapse / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / magnesium ion binding / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / cytoplasm / cytosol類似検索 - 分子機能 Ribosomal S6 kinase, N-terminal catalytic domain / Ribosomal protein S6 kinase II / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 ...Ribosomal S6 kinase, N-terminal catalytic domain / Ribosomal protein S6 kinase II / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 DI(HYDROXYETHYL)ETHER / Ribosomal protein S6 kinase alpha-1類似検索 - 構成要素 |
---|
生物種 | HOMO SAPIENS (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
---|
データ登録者 | Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. ...Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Knapp, S. |
---|
引用 | ジャーナル: To be Published タイトル: Crystal Structure of the Human Ribosomal Protein S6 Kinase 著者: Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Knapp, S. |
---|
履歴 | 登録 | 2009年7月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2009年8月25日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年5月8日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.3 | 2018年1月24日 | Group: Database references / Structure summary / カテゴリ: audit_author / citation_author / Item: _audit_author.name / _citation_author.name |
---|
|
---|