Entry | Database: PDB / ID: 2wb8 |
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Title | Crystal structure of Haspin kinase |
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Components | SERINE/THREONINE-PROTEIN KINASE HASPIN |
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Keywords | TRANSFERASE / HISTONE MODIFICATION / PHOSPHOPROTEIN / ATYPICAL KINASE / SERINE/THREONINE-PROTEIN KINASE / NUCLEOTIDE-BINDING / CHROMATIN REGULATOR / CELL CYCLE / HISTONE H3 / ATP-BINDING / GSG2 / KINASE / HASPIN / NUCLEUS / MITOSIS |
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Function / homology | Function and homology information
histone H3T3 kinase activity / protein localization to chromosome, centromeric region / mitotic sister chromatid cohesion / mitotic spindle assembly checkpoint signaling / spindle / chromosome / mitotic cell cycle / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction ...histone H3T3 kinase activity / protein localization to chromosome, centromeric region / mitotic sister chromatid cohesion / mitotic spindle assembly checkpoint signaling / spindle / chromosome / mitotic cell cycle / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / centrosome / nucleoplasm / ATP binding / nucleus / cytoplasmSimilarity search - Function Serine/threonine-protein kinase haspin, C-terminal / Domain of unknown function / Haspin like kinase domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ...Serine/threonine-protein kinase haspin, C-terminal / Domain of unknown function / Haspin like kinase domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 2.15 Å |
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Authors | Villa, F. / Tortorci, M. / Forneris, F. / Mattevi, A. / Musacchio, A. |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2009 Title: Crystal Structure of the Catalytic Domain of Haspin, an Atypical Kinase Implicated in Chromatin Organization. Authors: Villa, F. / Capasso, P. / Tortorici, M. / Forneris, F. / De Marco, A. / Mattevi, A. / Musacchio, A. |
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History | Deposition | Feb 23, 2009 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 10, 2009 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | May 8, 2024 | Group: Data collection / Database references / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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