Entry Database : PDB / ID : 2wa0 Structure visualization Downloads & linksTitle Crystal structure of the human MAGEA4 ComponentsMELANOMA-ASSOCIATED ANTIGEN 4 Details Keywords IMMUNE SYSTEM / MULTIPLE ANOMALOUS DISPERSION / CANCER/TESTIS ANTIGEN 1.4 / MELANOMA ANTIGEN FAMILY A 4 / CT1.4 / MAGE-41 / MAGE-X2 / TUMOR ANTIGEN / MELANOMA-ASSOCIATED ANTIGEN 4Function / homology Function and homology informationFunction Domain/homology Component
positive regulation of cell cycle / histone deacetylase binding / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / nucleus Similarity search - Function MAGE homology domain, winged helix WH1 motif / MAGE homology domain, winged helix WH2 motif / Melanoma associated antigen, N-terminal / Melanoma associated antigen family N terminal / Melanoma associated antigen family N terminal / MAGE conserved domain profile. / MAGE homology domain / Melanoma-associated antigen / MAGE homology domain, winged helix WH1 motif / MAGE homology domain, winged helix WH2 motif ... MAGE homology domain, winged helix WH1 motif / MAGE homology domain, winged helix WH2 motif / Melanoma associated antigen, N-terminal / Melanoma associated antigen family N terminal / Melanoma associated antigen family N terminal / MAGE conserved domain profile. / MAGE homology domain / Melanoma-associated antigen / MAGE homology domain, winged helix WH1 motif / MAGE homology domain, winged helix WH2 motif / MAGE homology domain / Melanoma-associated antigen / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MIRAS / Resolution : 2.3 Å DetailsAuthors Roos, A.K. / Cooper, C.D.O. / Ugochukwu, E. / W Yue, W. / Berridge, G. / Elkins, J.M. / Pike, A.C.W. / Bray, J. / Filippakopoulos, P. / Muniz, J. ...Roos, A.K. / Cooper, C.D.O. / Ugochukwu, E. / W Yue, W. / Berridge, G. / Elkins, J.M. / Pike, A.C.W. / Bray, J. / Filippakopoulos, P. / Muniz, J. / Chaikuad, A. / Burgess-Brown, N. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Bountra, C. / von Delft, F. / Gileadi, O. / Oppermann, U. CitationJournal : Plos One / Year : 2016Title : Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.Authors : Newman, J.A. / Cooper, C.D.O. / Roos, A.K. / Aitkenhead, H. / Oppermann, U.C.T. / Cho, H.J. / Osman, R. / Gileadi, O. History Deposition Jan 31, 2009 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 10, 2009 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Apr 29, 2015 Group : Data collection / Refinement descriptionRevision 1.3 Mar 9, 2016 Group : Database referencesRevision 1.4 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.5 May 8, 2024 Group : Data collection / Database references / OtherCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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