|Entry||Database: PDB / ID: 2vxd|
|Title||The structure of the C-terminal domain of Nucleophosmin|
|Keywords||NUCLEAR PROTEIN / CHROMOSOMAL REARRANGEMENT / PROTO-ONCOGENE / PHOSPHOPROTEIN / ALTERNATIVE SPLICING / AML / NUCLEUS / NUCLEOLUS / RNA-BINDING / ACETYLATION|
|Function / homology|
Function and homology information
regulation of mRNA stability involved in cellular response to UV / regulation of eIF2 alpha phosphorylation by dsRNA / positive regulation of cell cycle G2/M phase transition / regulation of endoribonuclease activity / negative regulation of centrosome duplication / regulation of endodeoxyribonuclease activity / granular component / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / positive regulation of centrosome duplication / regulation of centriole replication ...regulation of mRNA stability involved in cellular response to UV / regulation of eIF2 alpha phosphorylation by dsRNA / positive regulation of cell cycle G2/M phase transition / regulation of endoribonuclease activity / negative regulation of centrosome duplication / regulation of endodeoxyribonuclease activity / granular component / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / positive regulation of centrosome duplication / regulation of centriole replication / positive regulation of protein localization to nucleolus / negative regulation of protein kinase activity by regulation of protein phosphorylation / regulation of centrosome duplication / Tat protein binding / cell volume homeostasis / nucleocytoplasmic transport / spindle pole centrosome / Nuclear import of Rev protein / centrosome cycle / rRNA export from nucleus / protein kinase inhibitor activity / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / regulation of DNA damage response, signal transduction by p53 class mediator / ribosomal large subunit binding / negative regulation of mRNA splicing, via spliceosome / ribosomal large subunit export from nucleus / ribosomal small subunit export from nucleus / ribosomal small subunit binding / Deposition of new CENPA-containing nucleosomes at the centromere / NF-kappaB binding / ribosomal large subunit biogenesis / ribosomal small subunit biogenesis / cell aging / core promoter sequence-specific DNA binding / positive regulation of protein kinase activity / positive regulation of protein ubiquitination / ribosome assembly / SUMOylation of transcription cofactors / intracellular protein transport / protein localization / regulation of cell growth / positive regulation of translation / nucleosome assembly / protein-DNA complex / cellular response to UV / DNA-binding transcription factor binding / large ribosomal subunit / unfolded protein binding / ribonucleoprotein complex / small ribosomal subunit / histone binding / protein N-terminus binding / chromatin remodeling / protein stabilization / rRNA binding / transcription coactivator activity / positive regulation of NF-kappaB transcription factor activity / nuclear speck / centrosome / negative regulation of cell population proliferation / DNA repair / focal adhesion / chromatin binding / nucleolus / positive regulation of cell population proliferation / negative regulation of apoptotic process / protein kinase binding / positive regulation of transcription, DNA-templated / signal transduction / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / protein-containing complex / RNA binding / membrane / nucleoplasm / nucleus / cytosol / cytoplasm
Similarity search - Function
Nucleophosmin, C-terminal domain / Nucleophosmin C-terminal domain / Nucleophosmin, C-terminal / Nucleoplasmin core domain / Nucleoplasmin core domain superfamily / Nucleoplasmin/nucleophosmin domain / Nucleoplasmin family / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Similarity search - Component
|Biological species||HOMO SAPIENS (human)|
|Authors||Bycroft, M. / Grummitt, C.G.|
|Citation||Journal: J.Biol.Chem. / Year: 2008|
Title: Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia.
Authors: Grummitt, C.G. / Townsley, F.M. / Johnson, C.M. / Warren, A.J. / Bycroft, M.
|Structure viewer||Molecule: |
Downloads & links
|#1: Protein|| |
Mass: 6183.121 Da / Num. of mol.: 1 / Fragment: C-TERMINAL DOMAIN, RESIDUES 214-265
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) HOMO SAPIENS (human) / Production host: ESCHERICHIA COLI (E. coli) / References: UniProt: P06748
|Sequence details||TWO EXTRA GLYCINE RESIDUES AT THE N-TERMINUS|
|Experiment||Method: SOLUTION NMR|
|NMR details||Text: NONE|
|Details||Contents: 10% WATER/90% D2O|
|Sample conditions||Ionic strength: 150 mM / pH: 6.5 / Pressure: 1.0 atm / Temperature: 298.0 K|
|Refinement||Software ordinal: 1 |
Details: REFINEMENT DETAILS CAN BE FOUND IN THE JRNL CITATION ABOVE
|NMR ensemble||Conformer selection criteria: LEAST RESTRAINT VIOLATION / Conformers calculated total number: 150 / Conformers submitted total number: 20|
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