Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB / monoamine oxidase activity / monoamine oxidase / phenylethylamine catabolic process / positive regulation of dopamine metabolic process / response to aluminum ion / negative regulation of serotonin secretion / response to selenium ion / primary-amine oxidase / aliphatic amine oxidase activity ...Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB / monoamine oxidase activity / monoamine oxidase / phenylethylamine catabolic process / positive regulation of dopamine metabolic process / response to aluminum ion / negative regulation of serotonin secretion / response to selenium ion / primary-amine oxidase / aliphatic amine oxidase activity / dopamine catabolic process / primary methylamine oxidase activity / mitochondrial envelope / hydrogen peroxide biosynthetic process / response to corticosterone / substantia nigra development / response to toxic substance / flavin adenine dinucleotide binding / response to ethanol / mitochondrial outer membrane / response to lipopolysaccharide / electron transfer activity / response to xenobiotic stimulus / neuronal cell body / dendrite / mitochondrion / identical protein binding Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 437 / Source method: isolated from a natural source / Formula: H2O
Nonpolymer details
THE COMPOUND USED FOR CO-CRYSTALLIZATION IS THE MAO B INHIBITOR PHENYLETHYLHYDRAZINE, WHICH IS ...THE COMPOUND USED FOR CO-CRYSTALLIZATION IS THE MAO B INHIBITOR PHENYLETHYLHYDRAZINE, WHICH IS MODIFIED BY THE PROTEIN PRODUCING A COMPOUND THAT CORRESPONDS TO PHENYLETHANE BOUND TO FAD.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.7 Å3/Da / Density % sol: 54 % / Description: NONE
Crystal grow
Details: 12% PEG4000, 100MM ADA PH 6.5, 70MM LITHIUM SULPHATE
Method to determine structure: OTHER / Resolution: 2.3→15 Å / Cor.coef. Fo:Fc: 0.926 / Cor.coef. Fo:Fc free: 0.887 / SU B: 6.273 / SU ML: 0.156 / Cross valid method: THROUGHOUT / ESU R: 0.308 / ESU R Free: 0.229 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.246
1416
2.6 %
RANDOM
Rwork
0.2
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obs
0.201
53412
97.5 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: BABINET MODEL WITH MASK