Entry Database : PDB / ID : 2vm5 Structure visualization Downloads & linksTitle HUMAN BIR2 DOMAIN OF BACULOVIRAL INHIBITOR OF APOPTOSIS REPEAT- CONTAINING 1 (BIRC1) ComponentsBACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 Details Keywords APOPTOSISFunction / homology Function and homology informationFunction Domain/homology Component
IPAF inflammasome complex / icosanoid biosynthetic process / canonical inflammasome complex / pattern recognition receptor signaling pathway / cysteine-type endopeptidase inhibitor activity / pyroptotic inflammatory response / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / negative regulation of tumor necrosis factor-mediated signaling pathway / detection of bacterium / protein serine/threonine kinase binding ... IPAF inflammasome complex / icosanoid biosynthetic process / canonical inflammasome complex / pattern recognition receptor signaling pathway / cysteine-type endopeptidase inhibitor activity / pyroptotic inflammatory response / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / negative regulation of tumor necrosis factor-mediated signaling pathway / detection of bacterium / protein serine/threonine kinase binding / positive regulation of interleukin-1 beta production / positive regulation of JNK cascade / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of inflammatory response / nervous system development / basolateral plasma membrane / regulation of apoptotic process / negative regulation of neuron apoptotic process / defense response to bacterium / inflammatory response / innate immune response / apoptotic process / negative regulation of apoptotic process / ATP hydrolysis activity / ATP binding / metal ion binding / cytoplasm Similarity search - Function Baculoviral IAP repeat-containing protein 1 / NLRC4, helical domain / NLRC4 helical domain / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A ... Baculoviral IAP repeat-containing protein 1 / NLRC4, helical domain / NLRC4 helical domain / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Leucine-rich repeat domain superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Herman, M.D. / Welin, M. / Arrowsmith, C.H. / Berglund, H. / Busam, R.D. / Collins, R. / Dahlgren, L.G. / Edwards, A.M. / Flodin, S. / Flores, A. ...Herman, M.D. / Welin, M. / Arrowsmith, C.H. / Berglund, H. / Busam, R.D. / Collins, R. / Dahlgren, L.G. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, I. / Kallas, A. / Karlberg, T. / Kotenyova, T. / Lehtio, L. / Moche, M. / Nilsson, M.E. / Nyman, T. / Persson, C. / Sagemark, J. / Svensson, L. / Thorsell, A.G. / Tresaugues, L. / van den Berg, S. / Weigelt, J. / Nordlund, P. / Structural Genomics Consortium (SGC) CitationJournal : Acta Crystallogr.,Sect.F / Year : 2009Title : Structures of Bir Domains from Human Naip and Ciap2.Authors : Herman, M.D. / Moche, M. / Flodin, S. / Welin, M. / Tresaugues, L. / Johansson, I. / Nilsson, M.E. / Nordlund, P. / Nyman, T. History Deposition Jan 23, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 29, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Dec 28, 2011 Group : Database references / Derived calculations ... Database references / Derived calculations / Non-polymer description / Other / Structure summary / Version format compliance Revision 1.2 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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