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- PDB-2vd5: Structure of Human Myotonic Dystrophy Protein Kinase in Complex w... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2vd5 | ||||||
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Title | Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII | ||||||
![]() | DMPK PROTEIN | ||||||
![]() | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / KINASE / ATP-BINDING / NUCLEOTIDE-BINDING / CARDIAC CONTRACTILITY / MUSCLE DIFFERENTIATION | ||||||
Function / homology | ![]() regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction / muscle cell apoptotic process / regulation of skeletal muscle contraction by calcium ion signaling / myosin phosphatase regulator activity / regulation of myotube differentiation / : / regulation of synapse structural plasticity / nuclear envelope organization / actomyosin structure organization / nuclear outer membrane ...regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction / muscle cell apoptotic process / regulation of skeletal muscle contraction by calcium ion signaling / myosin phosphatase regulator activity / regulation of myotube differentiation / : / regulation of synapse structural plasticity / nuclear envelope organization / actomyosin structure organization / nuclear outer membrane / regulation of heart contraction / regulation of cardiac conduction / regulation of sodium ion transport / Ion homeostasis / sarcoplasmic reticulum membrane / intracellular calcium ion homeostasis / peptidyl-serine phosphorylation / nuclear membrane / mitochondrial outer membrane / cytoskeleton / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / ATP binding / metal ion binding / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Pike, A.C.W. / Amos, A. / Elkins, J. / Bullock, A. / Guo, K. / Fedorov, O. / Bunkoczi, G. / Filippakopoulos, P. / Pilka, E.S. / Ugochukwu, E. ...Pike, A.C.W. / Amos, A. / Elkins, J. / Bullock, A. / Guo, K. / Fedorov, O. / Bunkoczi, G. / Filippakopoulos, P. / Pilka, E.S. / Ugochukwu, E. / Umeano, C. / Niesen, F. / Sundstrom, M. / Weigelt, J. / Edwards, A. / Arrowsmith, C.H. / von Delft, F. / Knapp, S. | ||||||
![]() | ![]() Title: Structure of Dystrophia Myotonica Protein Kinase. Authors: Elkins, J. / Amos, A. / Niesen, F. / Pike, A.C.W. / Fedorov, O. / Knapp, S. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 160.1 KB | Display | ![]() |
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PDB format | ![]() | 125.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1.2 MB | Display | ![]() |
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Full document | ![]() | 1.2 MB | Display | |
Data in XML | ![]() | 27.5 KB | Display | |
Data in CIF | ![]() | 37.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2esmS S: Starting model for refinement |
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Similar structure data |
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Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1 / Refine code: 4
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