登録情報 データベース : PDB / ID : 2v5e 構造の表示 ダウンロードとリンクタイトル The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding. 要素GDNF FAMILY RECEPTOR ALPHA-1 GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR 詳細キーワード RECEPTOR/GLYCOPROTEIN COMPLEX / RECEPTOR-GLYCOPROTEIN COMPLEX / ALTERNATIVE SPLICING / CELL MEMBRANE / GROWTH FACTOR / LIGAND-CORECEPTOR / GPI-ANCHOR / LIPOPROTEIN / POLYMORPHISM / GLYCOPROTEIN / MEMBRANE / RECEPTOR / SECRETED / GFRALPHA1 / CLEAVAGE ON PAIR OF BASIC RESIDUES / RECEPTOR-GLYCOPROTEIN COMPLEX complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
chemoattractant activity involved in axon guidance / postsynaptic membrane organization / mesenchymal to epithelial transition involved in metanephros morphogenesis / dorsal spinal cord development / positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / ureteric bud formation / positive regulation of ureteric bud formation / regulation of semaphorin-plexin signaling pathway / postganglionic parasympathetic fiber development / positive regulation of monooxygenase activity ... chemoattractant activity involved in axon guidance / postsynaptic membrane organization / mesenchymal to epithelial transition involved in metanephros morphogenesis / dorsal spinal cord development / positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / ureteric bud formation / positive regulation of ureteric bud formation / regulation of semaphorin-plexin signaling pathway / postganglionic parasympathetic fiber development / positive regulation of monooxygenase activity / glial cell-derived neurotrophic factor receptor activity / glial cell-derived neurotrophic factor receptor binding / RET signaling / glial cell-derived neurotrophic factor receptor signaling pathway / regulation of morphogenesis of a branching structure / regulation of dopamine uptake involved in synaptic transmission / neurotrophin receptor activity / Formation of the ureteric bud / enteric nervous system development / peristalsis / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of dopamine secretion / sympathetic nervous system development / peripheral nervous system development / organ induction / regulation of stem cell differentiation / plasma membrane protein complex / metanephros development / commissural neuron axon guidance / NCAM1 interactions / mRNA stabilization / RAF/MAP kinase cascade / neural crest cell migration / branching involved in ureteric bud morphogenesis / RET signaling / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / embryonic organ development / multivesicular body / adult locomotory behavior / kidney development / positive regulation of cell differentiation / growth factor activity / neuron differentiation / receptor tyrosine kinase binding / male gonad development / neuron projection development / positive regulation of peptidyl-tyrosine phosphorylation / cell migration / integrin binding / nervous system development / signaling receptor activity / RAF/MAP kinase cascade / regulation of gene expression / negative regulation of neuron apoptotic process / receptor complex / external side of plasma membrane / axon / signaling receptor binding / neuronal cell body / positive regulation of cell population proliferation / negative regulation of apoptotic process / Golgi apparatus / signal transduction / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 : / Glial cell line-derived neurotrophic factor receptor, alpha 1 / Glial cell line-derived neurotrophic factor / Glial cell line-derived neurotrophic factor receptor, alpha 1/2 / Glial cell line-derived neurotrophic factor receptor / GDNF receptor alpha / Glial cell line-derived neurotrophic factor family / GDNF/GAS1 / GDNF/GAS1 domain / GDNF/GAS1 domain ... : / Glial cell line-derived neurotrophic factor receptor, alpha 1 / Glial cell line-derived neurotrophic factor / Glial cell line-derived neurotrophic factor receptor, alpha 1/2 / Glial cell line-derived neurotrophic factor receptor / GDNF receptor alpha / Glial cell line-derived neurotrophic factor family / GDNF/GAS1 / GDNF/GAS1 domain / GDNF/GAS1 domain / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon / Mainly Beta 類似検索 - ドメイン・相同性 sucrose octasulfate / Glial cell line-derived neurotrophic factor / GDNF family receptor alpha-1 類似検索 - 構成要素生物種 RATTUS NORVEGICUS (ドブネズミ)HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.35 Å 詳細データ登録者 Parkash, V. / Leppanen, V.-M. / Virtanen, H. / Jurvansuu, J.-M. / Bespalov, M.M. / Sidorova, Y.A. / Runeberg-Roos, P. / Saarma, M. / Goldman, A. 引用ジャーナル : J.Biol.Chem. / 年 : 2008タイトル : The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.著者 : Parkash, V. / Leppanen, V.-M. / Virtanen, H. / Jurvansuu, J.-M. / Bespalov, M.M. / Sidorova, Y.A. / Runeberg-Roos, P. / Saarma, M. / Goldman, A. 履歴 登録 2008年10月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2008年10月21日 Provider : repository / タイプ : Initial release改定 1.1 2014年2月5日 Group : Derived calculations / Non-polymer description ... Derived calculations / Non-polymer description / Other / Refinement description / Source and taxonomy / Structure summary / Version format compliance 改定 2.0 2020年7月29日 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Non-polymer description / Other / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type / _pdbx_database_status.status_code_sf / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_value_order / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2023年12月13日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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