|Entry||Database: PDB / ID: 2pld|
|Title||NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE|
|Keywords||PHOSPHORIC DIESTER HYDROLASE|
|Function / homology|
Function and homology information
platelet-derived growth factor-activated receptor activity / platelet activating factor receptor activity / metanephric glomerular mesangial cell proliferation involved in metanephros development / platelet-derived growth factor beta-receptor activity / cell migration involved in coronary angiogenesis / response to ceramide / metanephric mesenchymal cell migration / metanephric comma-shaped body morphogenesis / positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway / metanephric glomerular capillary formation ...platelet-derived growth factor-activated receptor activity / platelet activating factor receptor activity / metanephric glomerular mesangial cell proliferation involved in metanephros development / platelet-derived growth factor beta-receptor activity / cell migration involved in coronary angiogenesis / response to ceramide / metanephric mesenchymal cell migration / metanephric comma-shaped body morphogenesis / positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway / metanephric glomerular capillary formation / lung growth / smooth muscle cell chemotaxis / positive regulation of hepatic stellate cell activation / cell migration involved in vasculogenesis / aorta morphogenesis / retina vasculature development in camera-type eye / phosphoinositide phospholipase C / positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway / metanephric S-shaped body morphogenesis / metanephric mesenchyme development / platelet-derived growth factor binding / glycosaminoglycan biosynthetic process / phosphatidylinositol metabolic process / phospholipid catabolic process / cardiac myofibril assembly / positive regulation of chemotaxis / vascular endothelial growth factor binding / phosphatidylinositol phospholipase C activity / ruffle assembly / smooth muscle tissue development / response to fluid shear stress / COP9 signalosome / platelet-derived growth factor receptor binding / adrenal gland development / growth factor binding / positive regulation of Rho protein signal transduction / intrinsic component of plasma membrane / skeletal system morphogenesis / positive regulation of DNA biosynthetic process / tissue homeostasis / positive regulation of calcium ion import / positive regulation of smooth muscle cell migration / platelet-derived growth factor receptor signaling pathway / positive regulation of epithelial cell migration / positive regulation of phosphatidylinositol 3-kinase activity / platelet-derived growth factor receptor-beta signaling pathway / inner ear development / positive regulation of phosphoprotein phosphatase activity / phosphatidylinositol 3-kinase binding / embryonic organ development / regulation of peptidyl-tyrosine phosphorylation / response to hyperoxia / positive regulation of collagen biosynthetic process / regulation of actin cytoskeleton organization / positive regulation of phospholipase C activity / cellular response to vascular endothelial growth factor stimulus / response to retinoic acid / cell chemotaxis / phosphatidylinositol-mediated signaling / lysosomal lumen / cellular response to epidermal growth factor stimulus / positive regulation of mitotic nuclear division / ruffle / response to toxic substance / positive regulation of smooth muscle cell proliferation / receptor protein-tyrosine kinase / transmembrane receptor protein tyrosine kinase activity / positive regulation of fibroblast proliferation / cellular response to hydrogen peroxide / positive regulation of kinase activity / positive regulation of reactive oxygen species metabolic process / male gonad development / positive regulation of MAP kinase activity / peptidyl-tyrosine phosphorylation / wound healing / lamellipodium / cell migration / transmembrane receptor protein tyrosine kinase signaling pathway / in utero embryonic development / positive regulation of phosphatidylinositol 3-kinase signaling / response to estradiol / cytoplasmic vesicle / protein tyrosine kinase activity / apical plasma membrane / receptor complex / response to estrogen / positive regulation of ERK1 and ERK2 cascade / aging / MAPK cascade / intracellular signal transduction / multicellular organism development / positive regulation of cell migration / positive regulation of protein kinase B signaling / protein autophosphorylation / positive regulation of apoptotic process / intracellular membrane-bounded organelle / signaling receptor binding / focal adhesion / positive regulation of cell population proliferation / calcium ion binding
Tyrosine-protein kinase, receptor class III, conserved site / Immunoglobulin subtype 2 / Immunoglobulin-like fold / Immunoglobulin / Immunoglobulin I-set / EF-hand domain pair / Protein kinase-like domain superfamily / Tyrosine-protein kinase, active site / Immunoglobulin-like domain / Immunoglobulin subtype ...Tyrosine-protein kinase, receptor class III, conserved site / Immunoglobulin subtype 2 / Immunoglobulin-like fold / Immunoglobulin / Immunoglobulin I-set / EF-hand domain pair / Protein kinase-like domain superfamily / Tyrosine-protein kinase, active site / Immunoglobulin-like domain / Immunoglobulin subtype / EF-hand domain / Protein kinase, ATP binding site / Pleckstrin homology domain / Phospholipase C, phosphatidylinositol-specific, Y domain / SH3 domain / Serine-threonine/tyrosine-protein kinase, catalytic domain / Phosphoinositide phospholipase C family / SH2 domain / Phosphatidylinositol-specific phospholipase C, X domain / Protein kinase domain / C2 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PH-like domain superfamily / C2 domain superfamily / EF-Hand 1, calcium-binding site / Tyrosine-protein kinase, catalytic domain / SH2 domain / Platelet-derived growth factor receptor beta / Immunoglobulin-like domain superfamily / SH3-like domain superfamily / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / SH2 domain superfamily / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / SH2 domain / SHC Adaptor Protein / 2-Layer Sandwich / Alpha Beta
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / Platelet-derived growth factor receptor beta
|Biological species||Bos taurus (cattle)|
|Authors||Pascal, S.M. / Singer, A.U. / Gish, G. / Yamazaki, T. / Shoelson, S.E. / Pawson, T. / Kay, L.E. / Forman-Kay, J.D.|
|Citation||Journal: Cell(Cambridge,Mass.) / Year: 1994|
Title: Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Authors: Pascal, S.M. / Singer, A.U. / Gish, G. / Yamazaki, T. / Shoelson, S.E. / Pawson, T. / Kay, L.E. / Forman-Kay, J.D.
SummaryFull reportAbout validation report
|Structure viewer||Molecule: |
Downloads & links
A: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN
B: PHOSPHOPEPTIDE FROM PDGF
|Atom site foot note||1: RESIDUES A 1 - A 10, A 99 - A 105, B 1 - B 2, AND B 11 - B 12 ARE DISORDERED IN SOLUTION; THEREFORE, COORDINATES DISPLAY LARGE RMSD VALUES FOR THESE ATOMS.|
|#1: Protein|| |
Mass: 12275.924 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Bos taurus (cattle)
References: UniProt: P08487, phosphoinositide phospholipase C
|#2: Protein/peptide|| |
Mass: 1480.532 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Bos taurus (cattle) / References: UniProt: P09619
|Experiment||Method: SOLUTION NMR|
*PLUSMethod: other / Details: NMR
|NMR software||Name: X-PLOR / Developer: BRUNGER / Classification: refinement|
|NMR ensemble||Conformers submitted total number: 1|
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