- PDB-2pf4: Crystal structure of the full-length simian virus 40 small t anti... -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 2pf4
Title
Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit
Components
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Small T antigen
Keywords
HYDROLASE REGULATOR/VIRAL PROTEIN / PP2A / SV40 / small t / DnaJ / Aalpha subunit / HYDROLASE REGULATOR-VIRAL PROTEIN COMPLEX
Function / homology
Function and homology information
Inhibition of replication initiation of damaged DNA by RB1/E2F1 / ERKs are inactivated / Initiation of Nuclear Envelope (NE) Reformation / Cyclin A/B1/B2 associated events during G2/M transition / CTLA4 inhibitory signaling / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Negative regulation of MAPK pathway / Spry regulation of FGF signaling / Regulation of TP53 Degradation ...Inhibition of replication initiation of damaged DNA by RB1/E2F1 / ERKs are inactivated / Initiation of Nuclear Envelope (NE) Reformation / Cyclin A/B1/B2 associated events during G2/M transition / CTLA4 inhibitory signaling / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Negative regulation of MAPK pathway / Spry regulation of FGF signaling / Regulation of TP53 Degradation / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / meiotic spindle elongation / RAF activation / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Cyclin D associated events in G1 / PKR-mediated signaling / mitotic sister chromatid separation / regulation of meiotic cell cycle process involved in oocyte maturation / Degradation of beta-catenin by the destruction complex / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / protein phosphatase type 2A complex / meiotic sister chromatid cohesion, centromeric / DARPP-32 events / RHO GTPases Activate Formins / Separation of Sister Chromatids / Platelet sensitization by LDL / Loss of Nlp from mitotic centrosomes / Recruitment of mitotic centrosome proteins and complexes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of NuMA to mitotic centrosomes / ERK/MAPK targets / Anchoring of the basal body to the plasma membrane / female meiotic nuclear division / AURKA Activation by TPX2 / protein antigen binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / protein phosphatase regulator activity / Regulation of PLK1 Activity at G2/M Transition / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / protein serine/threonine phosphatase activity / T cell homeostasis / chromosome, centromeric region / lateral plasma membrane / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / chromosome segregation / symbiont-mediated suppression of host gene expression / host cell cytoplasm / protein heterodimerization activity / neuronal cell body / glutamatergic synapse / synapse / dendrite / host cell nucleus / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function
Monochromator: SINGLE CRYSTAL, CYLINDRICALLY BENT, SI(220) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength
Wavelength: 1 Å / Relative weight: 1
Reflection
Redundancy: 7.1 % / Av σ(I) over netI: 12 / Number: 441399 / Rmerge(I) obs: 0.071 / Χ2: 1.77 / D res high: 3.1 Å / D res low: 50 Å / Num. obs: 62490 / % possible obs: 98.1
In the structure databanks used in Yorodumi, some data are registered as the other names, "COVID-19 virus" and "2019-nCoV". Here are the details of the virus and the list of structure data.
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)
EMDB accession codes are about to change! (news from PDBe EMDB page)
The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
The EM Navigator/Yorodumi systems omit the EMD- prefix.
Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator
Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.
Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi