Entry Database : PDB / ID : 2orx Structure visualization Downloads & linksTitle Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin ComponentsNeuropilin-1 Details Keywords SIGNALING PROTEIN / MEMBRANE PROTEIN / Neuropilin / VEGF / TuftsinFunction / homology Function and homology informationFunction Domain/homology Component
Neurophilin interactions with VEGF and VEGFR / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / CRMPs in Sema3A signaling / Sema3A PAK dependent Axon repulsion / trigeminal nerve morphogenesis / regulation of axon extension involved in axon guidance / basal dendrite development / otic placode development / positive regulation of smooth muscle cell chemotaxis / protein localization to early endosome ... Neurophilin interactions with VEGF and VEGFR / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / CRMPs in Sema3A signaling / Sema3A PAK dependent Axon repulsion / trigeminal nerve morphogenesis / regulation of axon extension involved in axon guidance / basal dendrite development / otic placode development / positive regulation of smooth muscle cell chemotaxis / protein localization to early endosome / basal dendrite arborization / dichotomous subdivision of terminal units involved in salivary gland branching / retina vasculature morphogenesis in camera-type eye / regulation of vascular endothelial growth factor receptor signaling pathway / vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis / ventral trunk neural crest cell migration / sympathetic neuron projection guidance / facioacoustic ganglion development / trigeminal ganglion development / neurofilament / postsynapse organization / trigeminal nerve structural organization / sensory neuron axon guidance / facial nerve structural organization / gonadotrophin-releasing hormone neuronal migration to the hypothalamus / branchiomotor neuron axon guidance / renal artery morphogenesis / Signal transduction by L1 / axon extension involved in axon guidance / VEGF-activated neuropilin signaling pathway / negative regulation of axon extension involved in axon guidance / sympathetic neuron projection extension / blood vessel endothelial cell migration / vascular endothelial growth factor binding / retina vasculature development in camera-type eye / endothelial cell chemotaxis / motor neuron migration / axonogenesis involved in innervation / sympathetic ganglion development / neural crest cell migration involved in autonomic nervous system development / positive regulation of axon extension involved in axon guidance / positive regulation of platelet-derived growth factor receptor signaling pathway / vascular endothelial growth factor receptor activity / negative regulation of axon extension / angiogenesis involved in coronary vascular morphogenesis / neuropilin signaling pathway / sympathetic nervous system development / coronary artery morphogenesis / hepatocyte growth factor receptor signaling pathway / substrate-dependent cell migration, cell extension / outflow tract septum morphogenesis / semaphorin receptor activity / commissural neuron axon guidance / axon extension / positive regulation of vascular associated smooth muscle cell migration / motor neuron axon guidance / cell migration involved in sprouting angiogenesis / axonal fasciculation / regulation of Cdc42 protein signal transduction / sprouting angiogenesis / neural crest cell migration / positive regulation of filopodium assembly / artery morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / branching involved in blood vessel morphogenesis / cellular response to hepatocyte growth factor stimulus / retinal ganglion cell axon guidance / positive chemotaxis / dendrite development / growth factor binding / sorting endosome / positive regulation of focal adhesion assembly / semaphorin-plexin signaling pathway / platelet-derived growth factor receptor signaling pathway / endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / neuron development / vasculogenesis / vascular endothelial growth factor receptor signaling pathway / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of phosphorylation / positive regulation of stress fiber assembly / positive regulation of endothelial cell migration / GTPase activator activity / axon guidance / integrin-mediated signaling pathway / negative regulation of extrinsic apoptotic signaling pathway / mitochondrial membrane / neuron migration / wound healing / response to wounding / positive regulation of angiogenesis / positive regulation of peptidyl-tyrosine phosphorylation / nervous system development / heart development / heparin binding / growth cone / postsynaptic membrane / angiogenesis Similarity search - Function Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / MAM domain signature. / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / : / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Coagulation factors 5/8 type C domain (FA58C) signature 2. ... Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / MAM domain signature. / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / : / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Galactose-binding domain-like / Galactose-binding-like domain superfamily / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.4 Å DetailsAuthors Vander Kooi, C.W. / Jusino, M.A. / Perman, B. / Neau, D.B. / Bellamy, H.D. / Leahy, D.J. CitationJournal : Proc.Natl.Acad.Sci.Usa / Year : 2007Title : Structural basis for ligand and heparin binding to neuropilin B domainsAuthors : Vander Kooi, C.W. / Jusino, M.A. / Perman, B. / Neau, D.B. / Bellamy, H.D. / Leahy, D.J. History Deposition Feb 5, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 3, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Apr 21, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.3 Aug 30, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less