Entry Database : PDB / ID : 2nyr Structure visualization Downloads & linksTitle Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin ComponentsNAD-dependent deacetylase sirtuin-5 Details Keywords HYDROLASE / HISTONE DEACETYLASE / STRUCTURAL GENOMICS / STRUCTURAL GENOMICS CONSORTIUM / SGCFunction / homology Function and homology informationFunction Domain/homology Component
protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity ... protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity / protein deacetylation / NAD-dependent histone deacetylase activity / negative regulation of cardiac muscle cell apoptotic process / NAD+ binding / negative regulation of reactive oxygen species metabolic process / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / mitochondrion organization / response to nutrient levels / Transcriptional activation of mitochondrial biogenesis / mitochondrial intermembrane space / transferase activity / mitochondrial matrix / mitochondrion / zinc ion binding / nucleus / cytosol Similarity search - Function Sirtuin, class III / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily ... Sirtuin, class III / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.06 Å DetailsAuthors Min, J.R. / Antoshenko, T. / Allali-Hassani, A. / Dong, A. / Weigelt, J. / Sundstrom, M. / Arrowsmith, C.H. / Edwards, A.M. / Bochkarev, A. / Plotnikov, A.N. / Structural Genomics Consortium (SGC) CitationJournal : Structure / Year : 2007Title : Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.Authors : Schuetz, A. / Min, J. / Antoshenko, T. / Wang, C.L. / Allali-Hassani, A. / Dong, A. / Loppnau, P. / Vedadi, M. / Bochkarev, A. / Sternglanz, R. / Plotnikov, A.N. History Deposition Nov 21, 2006 Deposition site : RCSB / Processing site : RCSBSupersession Dec 19, 2006 ID : 2FZQ Revision 1.0 Dec 19, 2006 Provider : repository / Type : Initial releaseRevision 1.1 Oct 17, 2007 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Derived calculations / Version format complianceRevision 1.3 Aug 30, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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