Entry | Database: PDB / ID: 2n31 |
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Title | Tom1 negatively modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism |
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Components | Toll interacting protein variant |
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Keywords | IMMUNE SYSTEM |
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Function / homology | Function and homology information
interleukin-1, type I receptor binding / leukocyte activation / protein localization to endosome / Toll-like receptor binding / positive regulation of protein sumoylation / SUMO binding / ubiquitin conjugating enzyme binding / interleukin-1-mediated signaling pathway / extrinsic component of plasma membrane / epithelial cell differentiation ...interleukin-1, type I receptor binding / leukocyte activation / protein localization to endosome / Toll-like receptor binding / positive regulation of protein sumoylation / SUMO binding / ubiquitin conjugating enzyme binding / interleukin-1-mediated signaling pathway / extrinsic component of plasma membrane / epithelial cell differentiation / ubiquitin binding / autophagy / kinase binding / Interleukin-1 signaling / specific granule lumen / azurophil granule lumen / ubiquitin-dependent protein catabolic process / molecular adaptor activity / early endosome / nuclear body / inflammatory response / phosphorylation / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / perinuclear region of cytoplasm / signal transduction / protein-containing complex / extracellular exosome / extracellular region / cytoplasm / cytosolSimilarity search - Function Toll-interacting protein, C2 domain / Toll-interacting protein, CUE domain / CUE domain / Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) / Ubiquitin system component CUE / CUE domain profile. / UBA-like superfamily / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain ...Toll-interacting protein, C2 domain / Toll-interacting protein, CUE domain / CUE domain / Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) / Ubiquitin system component CUE / CUE domain profile. / UBA-like superfamily / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / C2 domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | SOLUTION NMR / DISTANCE GEOMETRY, SIMULATED ANNEALING |
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Model details | lowest energy, model1 |
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Authors | Xiao, S. / Armstrong, G. / Capelluto, D. |
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Citation | Journal: Structure / Year: 2015 Title: Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism. Authors: Xiao, S. / Brannon, M.K. / Zhao, X. / Fread, K.I. / Ellena, J.F. / Bushweller, J.H. / Finkielstein, C.V. / Armstrong, G.S. / Capelluto, D.G. |
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History | Deposition | May 19, 2015 | Deposition site: BMRB / Processing site: RCSB |
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Revision 1.0 | Sep 16, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 21, 2015 | Group: Database references |
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Revision 1.2 | Jun 14, 2023 | Group: Data collection / Database references / Other Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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Revision 1.3 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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