登録情報 | データベース: PDB / ID: 2mng |
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タイトル | Apo Structure of human HCN4 CNBD solved by NMR |
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要素 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
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キーワード | TRANSPORT PROTEIN / Cyclic AMP binding domain / CS-ROSETTA |
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機能・相同性 | 機能・相同性情報
voltage-gated potassium channel activity involved in SA node cell action potential depolarization / sinoatrial node development / HCN channels / regulation of cardiac muscle cell action potential involved in regulation of contraction / SA node cell action potential / HCN channel complex / membrane depolarization during SA node cell action potential / cellular response to cGMP / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity ...voltage-gated potassium channel activity involved in SA node cell action potential depolarization / sinoatrial node development / HCN channels / regulation of cardiac muscle cell action potential involved in regulation of contraction / SA node cell action potential / HCN channel complex / membrane depolarization during SA node cell action potential / cellular response to cGMP / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity / membrane depolarization during cardiac muscle cell action potential / sodium ion import across plasma membrane / blood circulation / voltage-gated sodium channel activity / regulation of heart rate by cardiac conduction / voltage-gated potassium channel activity / potassium ion import across plasma membrane / monoatomic cation transport / regulation of cardiac muscle contraction / sodium ion transmembrane transport / muscle contraction / cAMP binding / cellular response to cAMP / potassium ion transmembrane transport / regulation of heart rate / regulation of membrane potential / axon / dendrite / perinuclear region of cytoplasm / identical protein binding / plasma membrane類似検索 - 分子機能 : / Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain ...: / Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / Jelly Rolls / RmlC-like jelly roll fold / Ion transport domain / Ion transport protein / Jelly Rolls / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR |
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Model details | closest to the average, model10 |
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データ登録者 | Akimoto, M. / Zhang, Z. / Boulton, S. / Selvaratnam, R. / VanSchouwen, B. / Gloyd, M. / Accili, E.A. / Lange, O.F. / Melacini, G. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2014 タイトル: A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. 著者: Akimoto, M. / Zhang, Z. / Boulton, S. / Selvaratnam, R. / VanSchouwen, B. / Gloyd, M. / Accili, E.A. / Lange, O.F. / Melacini, G. |
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履歴 | 登録 | 2014年4月3日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2014年6月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年2月11日 | Group: Database references |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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